NOSTRIN Antibody

Datasheet

Code	CSB-PA818236LA01HU
Size	US$166
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Image	Western blot All lanes: NOSTRIN antibody at 6µg/ml Lane 1: Mouse heart tissue Lane 2: Mouse brain tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 58, 55, 49, 65 kDa Observed band size: 58 kDa Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA818236LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA818236LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NOSTRIN Polyclonal antibody

Uniprot No.

Q8IVI9

Target Names

NOSTRIN

Alternative Names

BM247 antibody; BM247 homolog antibody; DaIP2 antibody; eNOS-trafficking inducer antibody; mDaIP2 antibody; MGC20702 antibody; Nitric oxide synthase traffic inducer antibody; Nitric oxide synthase trafficker antibody; NOSTN_HUMAN antibody; Nostrin antibody; RP23-431D4.2 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Nostrin protein (1-322AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The NOSTRIN Antibody (Product code: CSB-PA818236LA01HU) is Non-conjugated. For NOSTRIN Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA818236LB01HU	NOSTRIN Antibody, HRP conjugated	ELISA
FITC	CSB-PA818236LC01HU	NOSTRIN Antibody, FITC conjugated
Biotin	CSB-PA818236LD01HU	NOSTRIN Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.

Gene References into Functions

The suggest that scores obtained with the worst nostril are the most efficient in detecting an olfactory disorder. PMID: 28981819
NOSTRIN inhibited production of nitric oxide (NO) by suppressing the activation of endothelial nitric oxide synthase (eNOS). PMID: 27401251
no significant difference in serum level associated with preeclampsia or intrauterine growth restriction PMID: 24588201
This study showed that overexpression of NOSTRIN had a significant effect on eNOS activity in HUVECs and resulted in significant cellular damage. PMID: 23592143
The expression of NOSTRIN is decreased, while the activity of eNOS and the level of NO2-/NO3- increased in the testis tissue of azoospermia patients. PMID: 21351530
Results reveal an elegant mechanism of eNOS regulation by PECAM-1 through signal transducers and activators of transcription 3-mediated transcriptional control of NOSTRIN. PMID: 21183735
NOSTRIN expression was increased in umbilical vessel of women with pre-eclampsia. PMID: 19399414
NOSTRIN modulates nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. PMID: 12446846
NOSTRIN may facilitate endocytosis of endothelial nitric oxide synthase by coordinating the function of dynamin and the actin nucleation promoting factor N-WASP. PMID: 16234328
A ternary complex between NOSTRIN, caveolin-1, and eNOS mediates translocation of eNOS, with important implications for the activity and availability of eNOS in the cell. PMID: 16807357
results suggest that nuclear NOSTRINbeta may negatively regulate transcription of the NOSTRIN gene PMID: 18980613

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Subcellular Location

[Isoform 1]: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Note=Enriched in selected actin structures (PubMed:16234328, PubMed:16376344).; [Isoform 3]: Nucleus.

Tissue Specificity

Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level).

Database Links

HGNC: 20203

OMIM: 607496

KEGG: hsa:115677

UniGene: Hs.189780

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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