NOTUM Antibody

Datasheet

Code	CSB-PA747435LA01HU
Size	$600
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Image	Western Blot Positive WB detected in: MCF7 whole cell lysate(20µg), PC-3 whole cell lysate(20µg), HepG2 whole cell lysate(20µg), K562 whole cell lysate(20µg), Hela whole cell lysate(20µg), Mouse Brain tissue lysate(20µg) All lanes: NOTUM antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 56 kDa Observed band size: 56 kDa Exposure time: 120s
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NOTUM Polyclonal antibody

Uniprot No.

Q6P988

Target Names

NOTUM

Alternative Names

NOTUM antibody; notum pectinacetylesterase homolog (Drosophila) antibody; Notum pectinacetylesterase homolog antibody; NOTUM_HUMAN antibody; Protein notum homolog antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Palmitoleoyl-protein carboxylesterase NOTUM protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The NOTUM Antibody (Product code: CSB-PA747435LA01HU) is Non-conjugated. For NOTUM Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA747435LB01HU	NOTUM Antibody, HRP conjugated	ELISA
FITC	CSB-PA747435LC01HU	NOTUM Antibody, FITC conjugated
Biotin	CSB-PA747435LD01HU	NOTUM Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.

Gene References into Functions

NOTUM expression was increased in metastatic cells. Proliferation was suppressed by inhibiting expression of NOTUM. Knockdown of NOTUM genes inhibited proliferation as well as migration, with possible involvement of p38 and c-JUN N-terminal kinase in this process. PMID: 30343282
Data show that notum and glypican-1 and glypican-3 gene expression during colorectal cancer (CRC) development and present evidence to suggest them as potential new biomarkers of CRC pathogenesis. PMID: 26517809
Kinetic and mass spectrometric analyses of human proteins show that Notum is a carboxylesterase that removes an essential palmitoleate moiety from Wnt proteins and thus constitutes the first known extracellular protein deacylase PMID: 25731175
Overexpression of NOTUM is associated with hepatocellular carcinoma PMID: 18429952

Subcellular Location

Secreted.

Protein Families

Pectinacetylesterase family, Notum subfamily

Tissue Specificity

Rarely expressed in adult normal tissues.

Database Links

HGNC: 27106

OMIM: 609847

KEGG: hsa:147111

STRING: 9606.ENSP00000387310

UniGene: Hs.106137

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Wnt signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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