NRARP Antibody, FITC conjugated

Code CSB-PA016069LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NRARP Polyclonal antibody
Uniprot No.
Target Names
NRARP
Alternative Names
MGC61598 antibody; Notch regulated ankyrin repeat containing protein antibody; NOTCH regulated ankyrin repeat protein antibody; Notch-regulated ankyrin repeat-containing protein antibody; nrarp antibody; NRARP_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Notch-regulated ankyrin repeat-containing protein (1-114AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal. Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis. During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain.
Gene References into Functions
  1. High NRARP expression is associated with papillary thyroid carcinoma progression. PMID: 28207739
  2. Downregulation of NRARP expression exerts significant antitumor activities against cell growth and invasion of thyroid cancer, that suggests a potential role of NRARP in thyroid cancer targeted therapy. PMID: 27364790
  3. NRARP may stimulate cell proliferation in human breast cancer. PMID: 24778018
Protein Families
NRARP family
Database Links

HGNC: 33843

KEGG: hsa:441478

STRING: 9606.ENSP00000349041

UniGene: Hs.535075

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