NSFL1C Antibody

Datasheet

Code	CSB-PA892163DSR1HU
Size	US$166
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Image	Western blot All lanes: NSFL1C antibody at 6.3μg/ml Lane 1: Mouse brain tissue Lane 2: A431 whole cell lysate Lane 3: 293T whole cell lysate Lane 4: Rat liver tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 41, 38, 29 kDa Observed band size: 41, 130 kDa Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA892163DSR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA892163DSR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NSFL1C Polyclonal antibody

Uniprot No.

Q9UNZ2

Target Names

NSFL1C

Alternative Names

DJ776F14.1 antibody; MGC3347 antibody; NSF1C_HUMAN antibody; NSFL1 (p97) cofactor (p47) antibody; NSFL1 cofactor p47 antibody; NSFL1C antibody; OTTHUMP00000029972 antibody; OTTHUMP00000029974 antibody; p47 antibody; P47 protein antibody; p97 cofactor p47 antibody; SHP1 homolog antibody; UBX domain protein 2C antibody; UBX domain-containing protein 2C antibody; UBX1 antibody; UBXD10 antibody; UBXN2C antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant Human NSFL1 cofactor p47 protein (1-185AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.

Gene References into Functions

p47 promotes, whereas SASK1 delays the degradation of a single ERAD substrate, alpha-TCR. Additionally, we found that SAKS1 selectively inhibits the degradation of ERAD substrates without affecting cytosolic proteasomal substrates. PMID: 27785701
The present results for the first time demonstrate that BDNF induces NADPH oxidase -derived reactive oxygen species generation through activation of p47 phox in a TrkB receptor-dependent manner PMID: 24612679
human p37/p47 and their C. elegans orthologue UBXN-2 regulate centrosome function in prophase by limiting the recruitment of Aurora A PMID: 23649807
The binding of p47 to polyubiquitinated NEMO triggers the lysosomal degradation of NEMO, thereby inhibiting IKK activation. PMID: 22990857

Subcellular Location

Nucleus. Golgi apparatus, Golgi stack. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Protein Families

NSFL1C family

Database Links

HGNC: 15912

OMIM: 606610

KEGG: hsa:55968

STRING: 9606.ENSP00000418529

UniGene: Hs.12865

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Protein processing in endoplasmic reticulum

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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