NTSR2 Antibody

Code CSB-PA008417
Size US$167
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Product Details

Uniprot No. O95665
Target Names NTSR2
Alternative Names Levocabastine sensitive neurotensin receptor antibody; Levocabastine-sensitive neurotensin receptor antibody; neurotensin receptor 2 antibody; Neurotensin receptor type 2 antibody; NT R 2 antibody; NT-R-2 antibody; NTR2 antibody; NTR2 receptor antibody; NTR2_HUMAN antibody; Ntsr2 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from the Internal region of Human NTR2.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:40000
Protocols Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Gene References into Functions
  1. We showed that expression levels for NTS and NTSR1 varied, that NTSR2 expression was not detectable and that NTSR3 was consistently expressed in all CRC cell lines examined. PMID: 28498396
  2. high expression of NTSR1 is found in clinical NETs and promoter methylation is an important mechanism controlling the differential expression of NTSR1 and silencing of NTSR2 in NET cells PMID: 26298774
  3. NTSR2 was overexpressed, NTSR1 decreased, and neurotensin was not expressed in B cell leukemia patient's B-cells, as compared with healthy B cells. PMID: 23109725
  4. this study proposes a novel function of NTR2 in the regulation of NTR1 activity. PMID: 19968961
  5. NTR2 and NTR3 were upregulated in prostate cancer cells with luminal phenotype (cytokeratin 18+) PMID: 20048080
  6. Recycling ability depends on a single tyrosine residue PMID: 11801734
  7. ghrelin receptor, neurotensin receptor 2 and GPR39 display an unusually high degree of constitutive activity, determined by an aromatic cluster on the inner face of the extracellular ends of TMs VI and VII PMID: 15383539
  8. NTR1 and NTR2 mRNA were not detected in either pituitary adenomas or normal tissue. PMID: 18624930

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Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 1 family, Neurotensin receptor subfamily, NTSR2 sub-subfamily
Tissue Specificity Expressed in prostate (at protein level).
Database Links

HGNC: 8040

OMIM: 605538

KEGG: hsa:23620

STRING: 9606.ENSP00000303686

UniGene: Hs.131138

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