NTSR2 Antibody

Code CSB-PA016138LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: U87 whole cell lysate
    All lanes: NTSR2 antibody at 3.2µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 46 kDa
    Observed band size: 46 kDa

  • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA016138LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA016138LA01HU at dilution of 1:100

  • Immunofluorescence staining of Hela cells with CSB-PA016138LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NTSR2 Polyclonal antibody
Uniprot No.
Target Names
NTSR2
Alternative Names
NTSR2; Neurotensin receptor type 2; NT-R-2; NTR2; Levocabastine-sensitive neurotensin receptor
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Neurotensin receptor type 2 protein (359-410AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The NTSR2 Antibody (Product code: CSB-PA016138LA01HU) is Non-conjugated. For NTSR2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA016138LB01HU NTSR2 Antibody, HRP conjugated ELISA
FITC CSB-PA016138LC01HU NTSR2 Antibody, FITC conjugated
Biotin CSB-PA016138LD01HU NTSR2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Gene References into Functions
  1. We showed that expression levels for NTS and NTSR1 varied, that NTSR2 expression was not detectable and that NTSR3 was consistently expressed in all CRC cell lines examined. PMID: 28498396
  2. high expression of NTSR1 is found in clinical NETs and promoter methylation is an important mechanism controlling the differential expression of NTSR1 and silencing of NTSR2 in NET cells PMID: 26298774
  3. NTSR2 was overexpressed, NTSR1 decreased, and neurotensin was not expressed in B cell leukemia patient's B-cells, as compared with healthy B cells. PMID: 23109725
  4. this study proposes a novel function of NTR2 in the regulation of NTR1 activity. PMID: 19968961
  5. NTR2 and NTR3 were upregulated in prostate cancer cells with luminal phenotype (cytokeratin 18+) PMID: 20048080
  6. Recycling ability depends on a single tyrosine residue PMID: 11801734
  7. ghrelin receptor, neurotensin receptor 2 and GPR39 display an unusually high degree of constitutive activity, determined by an aromatic cluster on the inner face of the extracellular ends of TMs VI and VII PMID: 15383539
  8. NTR1 and NTR2 mRNA were not detected in either pituitary adenomas or normal tissue. PMID: 18624930

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family, Neurotensin receptor subfamily, NTSR2 sub-subfamily
Tissue Specificity
Expressed in prostate (at protein level).
Database Links

HGNC: 8040

OMIM: 605538

KEGG: hsa:23620

STRING: 9606.ENSP00000303686

UniGene: Hs.131138

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