NUCB1 Antibody

1. Data suggest that calnuc (nucleobindin 1) is possibly involved in controlling protein unfolding diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), prion disease, and type II diabetes. PMID: 27997158
2. Calnuc depletion causes the misdelivery to and degradation in lysosomes of cationic-independent mannose-6-phosphate receptor and Sortilin . PMID: 26756199
3. nesfatin-1 has a role in thyroid dysfunction in patients with T2DM PMID: 24995340
4. The serine protease activity of calnuc is allosterically regulated by Zn2+ binding and its interaction with G protein alpha subunit. PMID: 23195954
5. postulate that the engineered forms of NUCB1 prevent hIAPP fibril formation by a mechanism where protofibril-like species are "capped" to prevent further fibril assembly and maturation PMID: 22542527
6. structural basis for the properties of Calnuc and NUCB2 binding to Galpha subunits and its regulation by calcium ions. PMID: 21653697
7. Nucleobindin 1 is a calcium-regulated guanine nucleotide dissociation inhibitor of G{alpha}i1. PMID: 20679342
8. Comparison between the structure of nucleobindin and other EF-hand proteins sheds light into the dual function of nucleobindin as Ca2+ storage (buffer) and Ca2+ sensor. PMID: 15287731
9. Calnuc protein may be a tumor-associated antigen (TAA) that induces autoantibody response in human cancers PMID: 17390015
10. NUCB1 is the first-identified, Golgi-localized negative feedback regulator in the ATF6-mediated branch of the UPR PMID: 17686766
11. results suggest that the functions of nucleobindins could be modulated by caspase-mediated cleavage in apoptosis PMID: 18154733
12. Proline residue at the +2-position (Pro(+2)) from the signal peptide cleavage site is the determinant of NUCB1 protein export from the ER and subsequent transport to the Golgi. PMID: 19656946

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HGNC: 8043

OMIM: 601323

KEGG: hsa:4924

STRING: 9606.ENSP00000263273

UniGene: Hs.631602