NUCKS1 Antibody

1. our results suggested that there was a significant association of a minor allele (G) in rs823114 with reduced risk of Parkinson's disease development (P = 0.017, OR = 0.768, 95%CI = 0.618 - 0.955). We conclude that NUCKS1 rs823114 indicates a decreased risk of susceptibility to Parkinson's disease and shows a male genetic distribution bias in the Han Chinese population. PMID: 29607885
2. High NUCKS1 expression is associated with drug resistance in lung cancer. PMID: 26989074
3. NUCKS overexpression had prognostic potential for overall survival and disease-free survival in advanced ovarian cancers and only for disease-free survival in early ovarian cancers . Our data suggest that NUCKS overexpression may contribute to progression and poor prognosis in ovarian cancer especially in advanced ovarian cancer PMID: 28877654
4. NUCKS1 was identified as a potential oncogene at chromosomal 1q32.1 in patients with HCC, and it might be a valuable immunodiagnostic marker for HCC PMID: 26968889
5. The results show that NUCKS1 is a chromatin-associated protein with a role in the DNA damage response and in homologous recombination, a DNA repair pathway critical for tumor suppression. PMID: 26323318
6. NUCKS is a physiological regulator of energy homeostasis and glucose metabolism that works by regulating chromatin accessibility and RNA polymerase II recruitment to the promoters of IR and other insulin pathway modulators. PMID: 24931609
7. NUCKS1 expression did not increase Tat nuclear localization. PMID: 25116364
8. NUCKS1 overexpression may be associated with tumour progression and recurrence in cervical squamous cell carcinoma PMID: 24819170
9. NUCKS-1 overexpression is associated with obesity and with breast cancer. PMID: 24568505
10. We would like to emphasize that NUCKS abundance in malignant skin tumors is higher than that of the well-known proliferation marker Ki67, thus allowing more precise assessment of tumor proliferation potential. PMID: 25119009
11. Authors suggest that NUCKS is involved in cellular responses following PDT. PMID: 24284105
12. The expression of Nucks in both proliferating and quiescent cells and its correlation with Bax levels and apoptosis strongly suggest that Nucks plays complex roles in cell homeostasis. PMID: 24140890
13. Through a combination of gene expression and copy number analysis, NUCKS1 was identified as a candidate gene involved in the distant metastasis of colorectal cancer. PMID: 23065711
14. The results show overexpression of the NUCKS protein and RNA in a number of non malignant breast lesions and cancerous tissues. In particular, the NUCKS overexpression in ADH and DCIS indicates a significant role of this protein in neoplastic progression. PMID: 19664271
15. Overexpression of NUCKS can play significant role in breast cancer biology. PMID: 20069058
16. Two putative nuclear localization signals have been identified and characterized in NUCKS. PMID: 17604136
17. NUCKS appears to have the highest ratio of modified to unmodified residues of any protein so far described. PMID: 18491381

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HGNC: 29923

OMIM: 611912

KEGG: hsa:64710

STRING: 9606.ENSP00000356110

UniGene: Hs.213061