HNUDC antibody; MNUDC antibody; MNUDC protein antibody; NPD011 antibody; Nuclear distribution C homolog antibody; Nuclear distribution gene C (A.nidulans) homolog antibody; Nuclear distribution gene C homolog antibody; Nuclear distribution gene C homolog (A. nidulans) antibody; Nuclear distribution protein C homolog antibody; Nuclear migration protein nudC antibody; nudC antibody; NudC nuclear distribution protein antibody; NUDC_HUMAN antibody; OTTHUMP00000004405 antibody; SIG 92 antibody; SIG92 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human NUDC
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
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Lead Time
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Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
Gene References into Functions
High expression of NUDC is associated with prostate cancer. PMID: 27959429
the upregulation of miR-194 affects the hNUDC expression, leading to a downregulated expression of Mpl/ERK pathway proteins, and suppresses the mitosis and proliferation of NSCLC cells. PMID: 27035759
NudC is co-localized with Aurora B at the midbody and co-immunoprecipitated with Aurora B in mitosis. results suggest that that dynamic phosphorylation of NudC by Aurora B regulates cytokinesis. PMID: 27074040
NudC acetylation/deacetylation regulates mitotic progression and NudC deacetylation, likely through HDAC3, is critical for spindle function and chromosome congression. PMID: 24069238
Human nuclear distribution C is found to be closely associated with cell malignant hyperplasia in nasopharyngeal carcinoma. PMID: 21473139
NudC may be involved in the regulation of LIS1 stability by its chaperone function. PMID: 20675372
separate binding sites on the Mpl receptor for TPO and hNUDC identified PMID: 20529857
Mpl plays an important and specific role in mediating hNUDC-induced megakaryocyte proliferation and differentiation. PMID: 19560457
functions in mitosis and cytokinesis, in part by regulating microtubule organization at the midzone and midbody PMID: 12679384
PLK1 phosphorylation of NudC plays an essential role in cytokinesis. PMID: 12852857
Overexpression of NUDC inhibits prostatic neoplasm growth. PMID: 14676831
In this study, we report the binding of hNUDC to the extracellular domain of the thrombopoietin receptor (Mpl) as detected by the yeast two-hybrid system, GST pull-down, and co-immunoprecipitation. PMID: 16088917
NudC functions as both a substrate and a spatial regulator of Plk1 at the kinetochore to promote chromosome congression. PMID: 16860740
hNUDC induced significant changes in cellular morphology in NIH 3T3 cells stably transfected with pMpl-EGFP. Interestingly, these morphological changes were characteristic of cells undergoing megakaryocyte differentiation. PMID: 17658515
hNUDC induced a sustained activation of the extracellular signal-regulated protein kinases-1 and -2 (ERK1/2) as well as p38 mitogen-activated kinase (p38 MAPK) pathways PMID: 18288130