NUDC Antibody

Code CSB-PA016148GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
NUDC
Alternative Names
HNUDC antibody; MNUDC antibody; MNUDC protein antibody; NPD011 antibody; Nuclear distribution C homolog antibody; Nuclear distribution gene C (A.nidulans) homolog antibody; Nuclear distribution gene C homolog antibody; Nuclear distribution gene C homolog (A. nidulans) antibody; Nuclear distribution protein C homolog antibody; Nuclear migration protein nudC antibody; nudC antibody; NudC nuclear distribution protein antibody; NUDC_HUMAN antibody; OTTHUMP00000004405 antibody; SIG 92 antibody; SIG92 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human NUDC
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
Gene References into Functions
  1. High expression of NUDC is associated with prostate cancer. PMID: 27959429
  2. the upregulation of miR-194 affects the hNUDC expression, leading to a downregulated expression of Mpl/ERK pathway proteins, and suppresses the mitosis and proliferation of NSCLC cells. PMID: 27035759
  3. NudC is co-localized with Aurora B at the midbody and co-immunoprecipitated with Aurora B in mitosis. results suggest that that dynamic phosphorylation of NudC by Aurora B regulates cytokinesis. PMID: 27074040
  4. NudC acetylation/deacetylation regulates mitotic progression and NudC deacetylation, likely through HDAC3, is critical for spindle function and chromosome congression. PMID: 24069238
  5. Human nuclear distribution C is found to be closely associated with cell malignant hyperplasia in nasopharyngeal carcinoma. PMID: 21473139
  6. NudC may be involved in the regulation of LIS1 stability by its chaperone function. PMID: 20675372
  7. separate binding sites on the Mpl receptor for TPO and hNUDC identified PMID: 20529857
  8. Mpl plays an important and specific role in mediating hNUDC-induced megakaryocyte proliferation and differentiation. PMID: 19560457
  9. functions in mitosis and cytokinesis, in part by regulating microtubule organization at the midzone and midbody PMID: 12679384
  10. PLK1 phosphorylation of NudC plays an essential role in cytokinesis. PMID: 12852857
  11. Overexpression of NUDC inhibits prostatic neoplasm growth. PMID: 14676831
  12. In this study, we report the binding of hNUDC to the extracellular domain of the thrombopoietin receptor (Mpl) as detected by the yeast two-hybrid system, GST pull-down, and co-immunoprecipitation. PMID: 16088917
  13. NudC functions as both a substrate and a spatial regulator of Plk1 at the kinetochore to promote chromosome congression. PMID: 16860740
  14. hNUDC induced significant changes in cellular morphology in NIH 3T3 cells stably transfected with pMpl-EGFP. Interestingly, these morphological changes were characteristic of cells undergoing megakaryocyte differentiation. PMID: 17658515
  15. hNUDC induced a sustained activation of the extracellular signal-regulated protein kinases-1 and -2 (ERK1/2) as well as p38 mitogen-activated kinase (p38 MAPK) pathways PMID: 18288130

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Subcellular Location
Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody.
Protein Families
NudC family
Tissue Specificity
Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart.
Database Links

HGNC: 8045

OMIM: 610325

KEGG: hsa:10726

STRING: 9606.ENSP00000319664

UniGene: Hs.263812

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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