NUMBL Antibody, Biotin conjugated

Datasheet

Code	CSB-PA897595LD01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NUMBL Polyclonal antibody

Uniprot No.

Q9Y6R0

Target Names

NUMBL

Alternative Names

CAG 3A antibody; CAG3A antibody; CTG 3a antibody; CTG3a antibody; NBL antibody; NUMB Drosophilia Homolog Like antibody; Numb homolog (Drosophila) like antibody; Numb homolog like antibody; Numb like protein antibody; NUMB R antibody; Numb-like protein antibody; Numb-R antibody; Numb-related gene antibody; Numb-related protein antibody; NUMBL antibody; NUMBL_HUMAN antibody; NUMBLIKE antibody; NUMBR antibody; TNRC 23 antibody; TNRC23 antibody; Trinucleotide repeat-containing gene 23 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Numb-like protein (447-576AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.

Gene References into Functions

NumbL can act as an independent tumor suppressor inhibiting the Notch pathway and regulating the cancer stem cell pool PMID: 27613838
let-7c inhibits Notch and progression markers but up-regulates Numbl in pancreatic cancer treated with quercetin PMID: 27521217
Numbl might be involved in the inhibition of growth, proliferation, and invasion of 95-D lung cancer cells. PMID: 23681800
Numbl-Klf4 signaling is critical to maintain multiple nodes of metastatic progression, including persistence of cancer-initiating cells. PMID: 23440423
data suggest that Numbl regulates glioma cell migration and invasion by abrogating TRAF5-induced activation of NF-KappaB PMID: 22593207
NUMBL interacts with TRAF6 and promotes the degradation of TRAF6 in vivo, leading to the inhibition of NF-kappaB signaling pathway. PMID: 20079715
Both gene sequence alterations and amplifications of LNX1 and Numbl are present in a subset of human gliomas. PMID: 18940473

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Subcellular Location

Cytoplasm.

Database Links

HGNC: 8061

OMIM: 604018

KEGG: hsa:9253

STRING: 9606.ENSP00000252891

UniGene: Hs.326953

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Notch signaling pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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