NUTM1 Antibody

1. Fluorescence in situ hybridization and targeted next-generation sequencing identified a CIC-NUTM1 fusion resulting from t(15;19)(q14;q13.2). In light of morphologic features that overlap with those of NC from typical anatomical sites we have seen previously, the tumor was best classified as falling within the NC spectrum rather than CIC-associated sarcoma. PMID: 29700887
2. Review and case series found that NUT midline carcinoma has dismal prognosis. Radiotherapy and chemotherapy improves survival, but do not provide long term control except in anecdotal cases. No impact on overall survival was found based on type of molecular translocation, i.e., NUT-BRD4, NUT-BRD3 or other variants. PMID: 29356890
3. We postulate that BRD4-NUT (B4N) complexes override the preexisting histone code with new posttranslational modifications patterns that reflect aberrant transcription and that epigenetically modulate the nucleosome environment toward the NUT-midline carcinoma (NMC) state. PMID: 27698495
4. we also identified a complex genomic rearrangement involving the BRD4-NUT rearrangement underlying the simple t(15;19) karyotype in Nuclear protein in testis (NUT) midline carcinoma PMID: 28203693
5. The clinical, radiographic, and histopathologic features of NUT midline carcinoma are discussed, as well as its management options. PMID: 24892275
6. NUT gene rearrangement does not seem to be relevant in primary pulmonary carcinomas or carcinoid tumours of the lung PMID: 26341600
7. Authors identified eight cases of primary pulmonary NMC over 4 years and, using a NUT immunohistochemistry screen, retrospectively identified one additional case from 166 consecutive biopsies of lung carcinomas lacking glandular differentiation. PMID: 26001144
8. discovered that the translocation oncoprotein BRD4-NUT protein occupies approximately 100-200 extremely broad, cell type-specific hyperacetylated domains in the genome PMID: 26220994
9. Thirty-seven (76%) malignant germ cell tumors were NUT positive but staining was usually of weak to moderate intensity and observed in a relatively small proportion of neoplastic cells. PMID: 25551299
10. Data support a model in which BRD4-NUT-stimulated histone hyperacetylation recruits additional BRD4 and interacting partners to support transcriptional activation, which underlies the BRD4-NUT oncogenic mechanism in NMC. PMID: 25512383
11. The involvement of the NSD3 methyltransferase as a component of the NUT fusion protein oncogenic complex identifies a new potential therapeutic target. PMID: 24875858
12. Case Report: NUT midline carcinoma in the nasal cavity with BRD4-NUT-rearrangement. PMID: 24655834
13. Four cases with the expression of P16 in NUT carcinomas with no association with human papillomavirus are being described. PMID: 24185123
14. Determination of NUT protein expression and gene rearrangement can allow the differentiation of NUT midline carcinoma from upper-respiratory tract poorly differentiated malignant tumors PMID: 22777717
15. immunohistochemical study of 21 cases revealed a lack of nuclear expression of NUT by undifferentiated (anaplastic) thyroid carcinomas PMID: 23701453
16. The novel BRD4-NUT fusion in which Exon 15 of BRD4 was fused to Exon 2 of NUT encodes a functional protein that is central to the oncogenic mechanism in these cells. PMID: 23128391
17. Only one thymic carcinoma (2.7% of thymic carcinomas or 0.68% of TETs) was found positive for NUT expression and rearrangement PMID: 22425924
18. Case Reports: 2 pediatric cases of nuclear protein of the testis (NUT) midline carcinoma suggestive of pulmonary origin. PMID: 22301500
19. study provides a novel mechanism by which the BRD4-NUT oncogene perturbs BRD4 functions to block cellular differentiation and to contribute to the oncogenic progression in the highly aggressive NUT midline carcinoma PMID: 21652721
20. NUT gene rearrangement is associated with squamous cell carcinoma of the lung with long time survival. PMID: 20871268
21. Using a patient-derived cell line, the authors show that p300 sequestration into the chromatin-bound BRD4-NUT fusion protein foci is the principal oncogenic mechanism leading to p53 inactivation. PMID: 20676058
22. Wild type Brd4 inhibits G(1) to S progression and we also found that the Brd4-NUT fusion augments the inhibition of progression to S phase compared with wild type Brd4. PMID: 15994877
23. BRD-NUT fusion proteins contribute to carcinogenesis by associating with chromatin and interfering with epithelial differentiation. PMID: 17934517
24. Approximately, 20% of undifferentiated carcinomas of the upper aerodigestive tract not associated with EBV infection were found to have rearrangements of NUT by FISH. PMID: 18391746
25. Some carcinomas of the upper aerodigestive tract have a rearrangement of the nuclear protein of the testis (NUT) gene (NUT midline carcinomas). PMID: 19550370

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HGNC: 29919

OMIM: 608963

KEGG: hsa:256646

STRING: 9606.ENSP00000329448

UniGene: Hs.525769