ORC2 Antibody

1. the ORC2 complex with E2 restricts viral replication in the maintenance phase of the viral replication program PMID: 27701460
2. ORC2 SUMOylation promotes recruitment of KDM5A to centromeres. PMID: 27052177
3. Protein phosphatase 1 dephosphorylates Orc2 to promote the binding of ORC to chromatin and replication origins for the subsequent round of the cell cycle. PMID: 24792176
4. These results suggest that PP1 dephosphorylates Orc2 to promote the binding of ORC to chromatin. PMID: 24732362
5. Gemcitabine resistance is dependent on Plk1-mediated phosphorylation of Orc2 and Hbo1. PMID: 23188630
6. Orc2 protects ORCA from ubiquitin-mediated degradation in vivo. PMID: 22935713
7. The phosphorylation of ORC2 dissociates origin recognition complex (ORC) from chromatin and replication origins and inhibits binding of ORC to newly replicated DNA. PMID: 22334659
8. Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress PMID: 21947279
9. the human origin recognition complex has a role in sequence-independent DNA binding and replication initiation PMID: 12897055
10. The precise nucleotide of binding for ORC2 was identified near the stgart site for leading-strand synthesis; the transition to the post-replicative complex is accompanied by a 17 bp displacement of ORC2 towards the start site. PMID: 12912926
11. Study using HCT116 haplo-insufficient cells and Orc2 hypomorphic cells demonstrates that human Ku80 and Orc2 bind to replication origins independently of each other. PMID: 15910003
12. The low level of Orc2 in Orc2 hypomorphic cells hinders normal cell cycle progression by delaying the activation of G1 cyclin-dependent kinases. PMID: 16407251
13. human Orc2 has specific domains that are required in vivo for assembly and nuclear localization of the origin recognition complex PMID: 16762929

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HGNC: 8488

OMIM: 601182

KEGG: hsa:4999

STRING: 9606.ENSP00000234296

UniGene: Hs.444870