OTOG Antibody, HRP conjugated

Code CSB-PA017273LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) OTOG Polyclonal antibody
Uniprot No.
Target Names
OTOG
Alternative Names
OTOG antibody; OTGN antibody; Otogelin antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Otogelin protein (1634-1796AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes.
Gene References into Functions
  1. Patients with OTOG mutation show a flat to downsloping configuration of the audiogram with mild to moderate sensorineural hearing loss. Speech recognition scores remain good and vestibular hyporeflexia is present. PMID: 24378291
  2. study reports the identification of mutations in OTOG as a cause of moderate nonsyndromic hearing loss PMID: 23122587
Involvement in disease
Deafness, autosomal recessive, 18B (DFNB18B)
Subcellular Location
Apical cell membrane; Peripheral membrane protein; Extracellular side. Secreted, extracellular space.
Protein Families
Otogelin family
Database Links

HGNC: 8516

OMIM: 604487

KEGG: hsa:340990

STRING: 9606.ENSP00000382323

UniGene: Hs.688380

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