OTOG Antibody

Code CSB-PA017273LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • IHC image of CSB-PA017273LA01HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of Hela cells with CSB-PA017273LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) OTOG Polyclonal antibody
Uniprot No. Q6ZRI0
Target Names OTOG
Alternative Names OTOG antibody; OTGN antibody; Otogelin antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Otogelin protein (1634-1796AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated

The OTOG Antibody (Product code: CSB-PA017273LA01HU) is Non-conjugated. For OTOG Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA017273LB01HU OTOG Antibody, HRP conjugated ELISA
FITC CSB-PA017273LC01HU OTOG Antibody, FITC conjugated
Biotin CSB-PA017273LD01HU OTOG Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
IF 1:50-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes.
Gene References into Functions
  1. Patients with OTOG mutation show a flat to downsloping configuration of the audiogram with mild to moderate sensorineural hearing loss. Speech recognition scores remain good and vestibular hyporeflexia is present. PMID: 24378291
  2. study reports the identification of mutations in OTOG as a cause of moderate nonsyndromic hearing loss PMID: 23122587
Involvement in disease Deafness, autosomal recessive, 18B (DFNB18B)
Subcellular Location Apical cell membrane; Peripheral membrane protein; Extracellular side. Secreted, extracellular space.
Protein Families Otogelin family
Database Links

HGNC: 8516

OMIM: 604487

KEGG: hsa:340990

STRING: 9606.ENSP00000382323

UniGene: Hs.688380

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