P4HB Antibody

Code CSB-PA823188YA01DXU
Size US$299
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Product Details

Full Product Name Rabbit anti-Cricetulus griseus P4HB Polyclonal antibody
Uniprot No. Q8R4U2
Target Names P4HB
Alternative Names P4HB antibody; PDIA1Protein disulfide-isomerase antibody; PDI antibody; EC 5.3.4.1 antibody; Prolyl 4-hydroxylase subunit beta antibody; p58 antibody
Raised in Rabbit
Species Reactivity Cricetulus griseus
Immunogen Recombinant Cricetulus griseus Protein disulfide-isomerase protein (20-509AA)
Immunogen Species Cricetulus griseus
Conjugate Non-conjugated

The P4HB Antibody (Product code: CSB-PA823188YA01DXU) is Non-conjugated. For P4HB Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA823188YB01DXU P4HB Antibody, HRP conjugated ELISA
FITC CSB-PA823188YC01DXU P4HB Antibody, FITC conjugated
Biotin CSB-PA823188YD01DXU P4HB Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.
Subcellular Location Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome. Cell membrane; Peripheral membrane protein.
Protein Families Protein disulfide isomerase family
Database Links

KEGG: cge:100689433

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