P4HB Antibody

^{Rare Species}

Datasheet

Code	CSB-PA823188YA01DXU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Cricetulus griseus P4HB Polyclonal antibody

Uniprot No.

Q8R4U2

Target Names

P4HB

Alternative Names

P4HB antibody; PDIA1Protein disulfide-isomerase antibody; PDI antibody; EC 5.3.4.1 antibody; Prolyl 4-hydroxylase subunit beta antibody; p58 antibody

Raised in

Rabbit

Species Reactivity

Cricetulus griseus

Immunogen

Recombinant Cricetulus griseus Protein disulfide-isomerase protein (20-509AA)

Immunogen Species

Cricetulus griseus

Conjugate

Non-conjugated

The P4HB Antibody (Product code: CSB-PA823188YA01DXU) is Non-conjugated. For P4HB Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA823188YB01DXU	P4HB Antibody, HRP conjugated	ELISA
FITC	CSB-PA823188YC01DXU	P4HB Antibody, FITC conjugated
Biotin	CSB-PA823188YD01DXU	P4HB Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.

Subcellular Location

Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome. Cell membrane; Peripheral membrane protein.

Protein Families

Protein disulfide isomerase family

Database Links

KEGG: cge:100689433

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The Overview of Organelles Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Protein processing in endoplasmic reticulum ER Stress pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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