PACS1 Antibody, Biotin conjugated

Code CSB-PA017371LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PACS1 Polyclonal antibody
Uniprot No.
Target Names
PACS1
Alternative Names
Cytosolic sorting protein PACS1 antibody; PACS 1 antibody; PACS-1 antibody; Pacs1 antibody; PACS1_HUMAN antibody; Phosphofurin acidic cluster sorting protein 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Phosphofurin acidic cluster sorting protein 1 protein (757-905AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.
Gene References into Functions
  1. Using whole exome sequencing (WES), we identified eight additional individuals with the same p.Arg203Trp missense variant in PACS1 that we demonstrated were de novo in seven individuals with available parental DNA. PMID: 28111752
  2. PCAF and ADA3 transcriptionally regulate PACS1 and PACS1 is a key regulator of BAX/BAK oligomerization and the intrinsic (mitochondrial) pathway to apoptosis. PMID: 28060382
  3. Protein adaptation and the expanding roles of the PACS1 and PACS2 proteins in tissue homeostasis and disease has been summarized. (Review) PMID: 28476937
  4. study showed for the first time that the rs564343 in phosphofurin acidic cluster sorting protein 1(PACS1) was associated with risk of severe obesity in Chinese children PMID: 28564656
  5. Clinical description of the PACS1-related syndrome has been reported in 19 unrelated patients. PMID: 26842493
  6. PACS1 plays an important role in protein sorting for amyloidogenic-burden control via both SORLA-dependent and SORLA-independent mechanisms. PMID: 24001769
  7. Single nucleotide polymorphisms in PAKS1 gene is associated with obesity. PMID: 23563609
  8. Our findings suggest that PACS1 is necessary for the formation of craniofacial structures and that perturbation of its functions results in a specific syndromic ID phenotype. PMID: 23159249
  9. The sites on Nef and the PACS proteins required for their interaction, are identified. PMID: 22496420
  10. PACS-1 along with HIV-1 nef, has a role in downregulating cell surface MHC-I to the trans-Golgi network and usurping the ARF6 endocytic pathway PMID: 12526811
  11. subcellular localization and function of polycystin-2 are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2 PMID: 15692563
  12. casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia PMID: 16308564
  13. CK2-activated phosphorylation cascade controlling PACS-1- and GGA3-mediated CI-MPR sorting, is reported. PMID: 16977309
  14. PACS-1 mediates phosphorylation-dependent ciliary trafficking of the CNGB1b in olfactory sensory neurons. PMID: 19710307

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Involvement in disease
Schuurs-Hoeijmakers syndrome (SHMS)
Subcellular Location
Golgi apparatus, trans-Golgi network.
Protein Families
PACS family
Database Links

HGNC: 30032

OMIM: 607492

KEGG: hsa:55690

STRING: 9606.ENSP00000316454

UniGene: Hs.644326

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