PACS1 Antibody

Code CSB-PA017371LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
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  • Western Blot
    Positive WB detected in: Raji whole cell lysate, Hela whole cell lysate
    All lanes: PACS1 antibody at 3.2µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 105, 110 kDa
    Observed band size: 110 kDa

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PACS1 Polyclonal antibody
Uniprot No. Q6VY07
Target Names PACS1
Alternative Names Cytosolic sorting protein PACS1 antibody; PACS 1 antibody; PACS-1 antibody; Pacs1 antibody; PACS1_HUMAN antibody; Phosphofurin acidic cluster sorting protein 1 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Phosphofurin acidic cluster sorting protein 1 protein (757-905AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.
Gene References into Functions
  1. Using whole exome sequencing (WES), we identified eight additional individuals with the same p.Arg203Trp missense variant in PACS1 that we demonstrated were de novo in seven individuals with available parental DNA. PMID: 28111752
  2. PCAF and ADA3 transcriptionally regulate PACS1 and PACS1 is a key regulator of BAX/BAK oligomerization and the intrinsic (mitochondrial) pathway to apoptosis. PMID: 28060382
  3. Protein adaptation and the expanding roles of the PACS1 and PACS2 proteins in tissue homeostasis and disease has been summarized. (Review) PMID: 28476937
  4. study showed for the first time that the rs564343 in phosphofurin acidic cluster sorting protein 1(PACS1) was associated with risk of severe obesity in Chinese children PMID: 28564656
  5. Clinical description of the PACS1-related syndrome has been reported in 19 unrelated patients. PMID: 26842493
  6. PACS1 plays an important role in protein sorting for amyloidogenic-burden control via both SORLA-dependent and SORLA-independent mechanisms. PMID: 24001769
  7. Single nucleotide polymorphisms in PAKS1 gene is associated with obesity. PMID: 23563609
  8. Our findings suggest that PACS1 is necessary for the formation of craniofacial structures and that perturbation of its functions results in a specific syndromic ID phenotype. PMID: 23159249
  9. The sites on Nef and the PACS proteins required for their interaction, are identified. PMID: 22496420
  10. PACS-1 along with HIV-1 nef, has a role in downregulating cell surface MHC-I to the trans-Golgi network and usurping the ARF6 endocytic pathway PMID: 12526811
  11. subcellular localization and function of polycystin-2 are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2 PMID: 15692563
  12. casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia PMID: 16308564
  13. CK2-activated phosphorylation cascade controlling PACS-1- and GGA3-mediated CI-MPR sorting, is reported. PMID: 16977309
  14. PACS-1 mediates phosphorylation-dependent ciliary trafficking of the CNGB1b in olfactory sensory neurons. PMID: 19710307

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Involvement in disease Schuurs-Hoeijmakers syndrome (SHMS)
Subcellular Location Golgi apparatus, trans-Golgi network
Protein Families PACS family
Database Links

HGNC: 30032

OMIM: 607492

KEGG: hsa:55690

STRING: 9606.ENSP00000316454

UniGene: Hs.644326

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