PADI3 Antibody, FITC conjugated

1. The two enzymes PADI3 and TGM3, responsible for posttranslational protein modifications, and their target structural protein TCHH are all involved in hair shaft formation. PMID: 27866708
2. Crystals of PAD3 obtained using polyethylene glycol 400 as a precipitant diffracted to 2.95 A resolution using synchrotron radiation PMID: 22684066
3. PAD3 is co-located with filaggrin within the filamentous matrix of the deeper corneocytes where the protein is deiminated. PMID: 16091842
4. PADI3 expression is driven by Sp1/Sp3 and NF-Y binding to the promoter region PMID: 16671893
5. cytoplasmic S100A3 within the cuticular layer is mostly co-localized with the type III isoform of peptidylarginine deiminase (PAD3) PMID: 18083705
6. Peptidylarginine deiminase Intergenic Enhancer is a strong enhancer of the PADI3 promoter in Ca2+-differentiated epidermal keratinocytes, and requires bound PMID: 18923650
7. These results reveal the molecular bases of the expression specificity of PADI1 and PADI3 during keratinocyte differentiation through a long-range enhancer and support a model of PADI gene regulation depending on c-Jun-JunD competition. PMID: 18952102

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HGNC: 18337

OMIM: 191480

KEGG: hsa:51702

STRING: 9606.ENSP00000364609

UniGene: Hs.149195