PAFAH2 Antibody, Biotin conjugated

Code CSB-PA857448LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PAFAH2 Polyclonal antibody
Uniprot No.
Target Names
PAFAH2
Alternative Names
PAFAH2Platelet-activating factor acetylhydrolase 2 antibody; cytoplasmic antibody; EC 3.1.1.47 antibody; Serine-dependent phospholipase A2 antibody; SD-PLA2 antibody; hSD-PLA2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Platelet-activating factor acetylhydrolase 2, cytoplasmic protein (1-206AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation. Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF. Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position.
Gene References into Functions
  1. Data show that the activity of plasma platelet activating factor acetylhydrolase (PAF-AH) increases in parallel with diabetic retinopathy (DR) severity. PMID: 26791393
  2. The oligomeric state of PAFAH-II drives functional protein trafficking. PAFAH-II localization to the membrane is critical for substrate acquisition and effective oxidative stress protection. PMID: 25707358
  3. presence of platelet-activating factor acetylhydrolase II in a restricted pattern in human skin; it is involved in protecting this organ against oxidative stress through the degradation of oxidatively modified bioactive phospholipids. PMID: 12406338
  4. Lp-PLA2 was higher in those with more extensive Coronary artery disease PMID: 17157859
  5. PAF-AH II exerts strong neuroprotective effects against ischemic injury: the neurological deficit scores, cerebral edema index, and relative infarction volume are all significantly lower in PAFAH2 transgenic mice than in wild-type mice. PMID: 17272759
  6. examines substrate specificity for intracellular and plasma PAF-AHs PMID: 11294621

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Subcellular Location
Cytoplasm. Membrane; Lipid-anchor. Endoplasmic reticulum membrane; Lipid-anchor.
Protein Families
Serine esterase family
Tissue Specificity
Broadly expressed in different tissues, but high in B- and T-lymphocytes. In brain, expression is restricted to amygdala and frontal cortex.
Database Links

HGNC: 8579

OMIM: 602344

KEGG: hsa:5051

STRING: 9606.ENSP00000363400

UniGene: Hs.477083

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