PALLD Antibody

1. Twist1 appears to require both palladin and collagen alpha1(VI) as downstream effectors for its prometastatic effects, which could be future therapeutic targets in cancer metastasis. PMID: 26973246
2. Palladin role in the vascular smooth muscle cell differentiation and gene expression PMID: 27088725
3. stromal palladin expression is a surrogate indicator of the treatment effect after chemoradiation therapy. PMID: 27023252
4. Study identified the actin-associated protein palladin as a key node in signaling pathways that result in fibroblast activation in the increased tissue stiffness of a tumor microenvironment PMID: 26200861
5. Palladin interacts with MT1-MMP to promote tumor cell invasion in breast carcinoma. PMID: 24989798
6. palladin functions as a dynamic scaffolding protein that promotes the assembly of dorsal stress fibers by recruiting VASP to these structures. PMID: 24496446
7. Palladin seems to regulate podosome and invodopodia formation through Rho GTPases. [Review] PMID: 24525547
8. A model whereby palladin-activated fibroblasts facilitate stromal-dependent metastasis and outgrowth of tumorigenic epithelium. PMID: 22291919
9. results indicate that palladin phosphorylation by ERK has an anti-migratory function, possibly by modulating interactions with molecules that regulate cell migration PMID: 22216253
10. Observations support the belief that stromal palladin assessments have clinical relevance thus validating the use of these 3D cultures to study both progressive RCC-associated stroma and stroma-dependent mechanisms affecting tumorigenesis. PMID: 21738681
11. Palladin may identify primary pancreatic endocrine neoplasms with a propensity to metastasize to the liver PMID: 21868544
12. these results suggested that palladin played a specific role in modulating the subcellular localization of the cytoplasmic ILKAP and promoting the ILKAP-induced apoptosis. PMID: 21782789
13. The A-allele of PALLD rs7439293 was not associated with progressive carotid atherosclerosis PMID: 21054356
14. upregulation of 85-90 kDa palladin isoform may play a role in the establishment of the tumor-associated fibroblasts phenotype, and thus in the formation of a desmoplastic tumor microenvironment PMID: 20436683
15. Akt signaling regulates the stability of palladin PMID: 21050850
16. Palladin is an integral component of adherens junctions and plays a role in the localization of E-cadherin to the junctions. The loss of palladin may be an integral part of EMT, an early step in the metastatic spread of colon carcinoma. PMID: 20811713
17. Akt1 phosphorylates palladin, inducing cytoskeletal reorganization and inhibiting the migration of breast cancer cells. PMID: 20471940
18. Quantitative analysis of erythrocyte membrane proteins revealed decrease in palladin from patients with homozygous and heterozygous forms of beta-thalassemia. PMID: 15310273
19. Our results suggest that palladin may play an important role in recruiting profilin to sites of actin dynamics. PMID: 16367745
20. These results identify palladin 4Ig as a novel marker of myofibroblast conversion in vitro and in vivo. PMID: 16794588
21. Study identifies palladin as the mutated gene in the pancreatic cancer susceptibility locus at 4q32-34 and validates abnormal expression of the gene in a famililal pancreatic cancer kindred. PMID: 17194196
22. Palladin RNA was overexpressed in the tissues from precancerous dysplasia and pancreatic adenocarcinoma in both the familial and the sporadic disease. PMID: 17228136
23. The function of LPP and palladin is context dependent, that they play a critical role in cytoskeletal remodeling, respond to signals induced by vascular injury as well as signals that induce smooth muscle cell hypertrophy, such as angiotension II. PMID: 17322171
24. Study concludes that the P239S variant does not appear to account for a significant fraction of hereditary or early-onset pancreas cancer. PMID: 17415588
25. PALLD was differentially expressed in sclerotic hippocampi compared to non-sclerotic ones. PMID: 17515952
26. The interplay between palladin, SPIN90 and Src and characterized the role of palladin and SPIN90 in platelet derived growth factor and Src-induced cytoskeletal remodeling, was analyzed. PMID: 17537434
27. Palladin was up-regulated in adipose-derived adult stem cells during osteogenic differentiation and cyclic tensile strain. PMID: 17687002
28. palladin overexpression contributes to the invasive behavior of metastatic cells. PMID: 18978809
29. expression of LPP and palladin are modulated by a mix of mechanical cues, oxidative stress and substrate composition which translate into their up or down regulation in vessel wall injury and early atherogenesis. PMID: 19205907
30. Single nucleotide polymorphisms in palladin is not associated with pancreatic cancer. PMID: 19336541

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HGNC: 17068

OMIM: 606856

KEGG: hsa:23022

STRING: 9606.ENSP00000425556

UniGene: Hs.151220