PAN2 Antibody

Code CSB-PA681391LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA681391LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA681391LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PAN2 Polyclonal antibody
Uniprot No. Q504Q3
Target Names PAN2
Alternative Names hPan2 antibody; Inactive ubiquitin carboxyl terminal hydrolase 52 antibody; Inactive ubiquitin carboxyl-terminal hydrolase 52 antibody; KIAA0710 antibody; PAB dependent poly(A) specific ribonuclease subunit 2 antibody; PAB-dependent poly(A)-specific ribonuclease subunit 2 antibody; PABP dependent poly(A) nuclease 2 antibody; PAN 2 antibody; PAN2 antibody; PAN2 homolog PABP1 dependent poly A specific ribonuclease subunit antibody; PAN2 poly(A) specific ribonuclease subunit homolog antibody; PAN2 polyA specific ribonuclease subunit homolog antibody; PAN2_HUMAN antibody; Ubiquitin specific peptidase 52 antibody; Ubiquitin specific protease 52 antibody; USP 52 antibody; USP52 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human PAB-dependent poly(A)-specific ribonuclease subunit PAN2 protein (628-908AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

(From Uniprot)
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.
Gene References into Functions
  1. USP52 is a bona fide ubiquitin-specific protease, and USP52 promotes ASF1A deubiquitination and stabilization. PMID: 29599486
  2. USP52 is a key component of P-bodies required to prevent HIF1A mRNA degradation PMID: 23398456
  3. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
  4. hPan2 and hPan3 have roles in mRNA decay and exhibit cytoplasmic co-localization PMID: 14583602
Subcellular Location Cytoplasm, Cytoplasm, P-body, Nucleus
Protein Families Peptidase C19 family, PAN2 subfamily
Database Links

HGNC: 20074

OMIM: 617447

KEGG: hsa:9924

STRING: 9606.ENSP00000401721

UniGene: Hs.273397


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