PANX3 Antibody

Datasheet

Code	CSB-PA839402LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate All lanes: PANX3 antibody at 4µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 45 kDa Observed band size: 45 kDa Immunofluorescence staining of HepG2 cells with CSB-PA839402LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PANX3 Polyclonal antibody

Uniprot No.

Q96QZ0

Target Names

PANX3

Alternative Names

PANX3; Pannexin-3

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Pannexin-3 protein (135-215AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PANX3 Antibody (Product code: CSB-PA839402LA01HU) is Non-conjugated. For PANX3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA839402LB01HU	PANX3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA839402LC01HU	PANX3 Antibody, FITC conjugated
Biotin	CSB-PA839402LD01HU	PANX3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Structural component of the gap junctions and the hemichannels.

Gene References into Functions

Panx3 was upregulated during osteogenic differentiation in a time-dependent manner. Panx3 overexpression promoted osteogenic differentiation of human dental pulp-derived mesenchymal stromal cells, whereas depletion of Panx3 resulted in a decline of differentiation. PMID: 29241211
Panx3 channels regulate the proliferation, differentiation, and fusion of skeletal muscle myoblasts. (Review) PMID: 27518505
Panx3 has a defensive role in dental pulp inflammation. PMID: 27679980
Case Report: osteosarcomatous transformation of axillary sweat gland neoplasm with high PANX3 expression. PMID: 27391460
Panx3 hemichannel is expressed in human odontoblast-like cells and mediates ATP release into the extracellular space. PMID: 26263540
Panx1 and Panx3 are co-expressed in human skeletal muscle myoblasts and play a pivotal role in dictating the proliferation and differentiation. PMID: 25239622
The 70 kDa immunoreactive species of Panx3 highly regulated during keratinocyte differentiation was shown to most likely correspond to another Panx3 isoform. PMID: 22947051
Panx3 functions to switch the chondrocyte cell fate from proliferation to differentiation by regulating the intracellular ATP/cAMP levels PMID: 20404334
although Panx1 and Panx3 share a common endoplasmic reticulum to Golgi secretory pathway to Cx43, their ultimate cell surface residency appears to be independent of cell contacts and the need for intact microtubules PMID: 20086016
These studies show that Panx1 and Panx3 have many characteristics that are distinct from Cx43 and that these proteins probably play an important biological role as single membrane channels. PMID: 17925379

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Protein Families

Pannexin family

Database Links

HGNC: 20573

OMIM: 608422

KEGG: hsa:116337

UniGene: Hs.99235

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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