PC Antibody

Datasheet

Code	CSB-PA017511GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

P11498

Target Names

Alternative Names

mitochondrial antibody; OTTHUMP00000235155 antibody; OTTHUMP00000235156 antibody; PC antibody; PCB antibody; Pcx antibody; PYC_HUMAN antibody; Pyruvate carboxylase antibody; Pyruvate carboxylase mitochondrial antibody; Pyruvic carboxylase antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human PC

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC,IF

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.

Gene References into Functions

PC enzyme activity is much higher in the highly invasive breast cancer cell line MDA-MB-231 than in less invasive breast cancer cell lines. Strong PC suppression lowered glucose incorporation into downstream metabolites of oxaloacetate, the product of the PC reaction, including malate, citrate and aspartate. PMID: 27890529
breast cancer cells proliferating as lung metastases activate PC-dependent anaplerosis in response to the lung microenvironment. PMID: 27732858
Pyruvate carboxylase activates the RIG-I-like receptor-mediated antiviral immune response by targeting the MAVS signalosome. PMID: 26906558
PC and PDH may be an important part of cellular adaptation to the IDH1 mutation and may serve as potential therapeutic targets PMID: 25243911
These findings indicate that PC-mediated anaplerosis in early-stage NSCLC is required for tumor survival and proliferation. PMID: 25607840
Increased PC expression is correlated with the malignant progression of GC, which might be a potential target for GC biotherapy. PMID: 23294723
characterization of PC distal promoter PMID: 23383084
PC protein is easily detectable by streptavidin blot and the presence of considerable amounts of PC in cultured human myotubes and in human muscle tissue was shown. PMID: 20807508
IVS15+2-5delTAGG results in the retention of intron 15 during pre-mRNA splicing and frameshift mutations. PMID: 12112657
expression and characterization of a variant by retroviral gene transfer PMID: 12437512
1 deficiency patient survived from neonatal lactic acidemia and shows an unusual subcortical leucodystrophic process. PMID: 16325442
The crystal structures at 2.8-A resolution of full-length PC from Staphylococcus aureus and the C-terminal region (missing only the BC domain) of human PC, is reported. PMID: 18297087
Eight novel mutations were identified in PC from 8 pyruvate carboxylase deficiency patients. PMID: 18676167
The activities of pyruvate carboxylase (PC) were decreased by 65% in pancreatic islets of patients with type 2 diabetes. PMID: 19296078
Nine novel mutations of the PC gene, in five unrelated patients, are reported. PMID: 19306334

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Involvement in disease

Pyruvate carboxylase deficiency (PC deficiency)

Subcellular Location

Mitochondrion matrix.

Database Links

HGNC: 8636

OMIM: 266150

KEGG: hsa:5091

STRING: 9606.ENSP00000377527

UniGene: Hs.89890

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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