PCBD1 Antibody

Code CSB-PA017514GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
PCBD1
Alternative Names
4 alpha hydroxy tetrahydropterin dehydratase antibody; 4-alpha-hydroxy-tetrahydropterin dehydratase antibody; 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) antibody; 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha antibody; DCoH antibody; Dimerization cofactor of hepatic nuclear factor 1 alpha antibody; Dimerization cofactor of hepatocyte nuclear factor 1 alpha antibody; Dimerization cofactor of hepatocyte nuclear factor 1-alpha antibody; Dimerization cofactor of HNF1 antibody; Dimerizing cofactor for HNF1 antibody; PCBD 1 antibody; PCBD antibody; PCBD1 antibody; PCD antibody; Phenylalanine hydroxylase stimulating protein antibody; Phenylalanine hydroxylase-stimulating protein antibody; PHS antibody; PHS_HUMAN antibody; Pterin 4 alpha carbinolamine dehydratase antibody; Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) antibody; Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha antibody; Pterin carbinolamine dehydratase antibody; Pterin-4-alpha-carbinolamine dehydratase antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human PCBD1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity. Also acts as a coactivator for HNF1B-dependent transcription.
Gene References into Functions
  1. We provide the first genetic evidence that PCBD1 mutations can cause early-onset nonautoimmune diabetes with features similar to dominantly inherited HNF1A-diabetes. PMID: 24848070
  2. Coactivator of the HNFB1 (HNF1 homeobox B)-mediated transcription is necessary for fine tuning ATPase Na+/K+ transporting gamma 1 polypeptide (FXYD2) transcription in the distal convoluted tubule PMID: 24204001
  3. Pcbd1 is a moonlighting protein that has dehydratase activity in addition to functioning as a cofactor which regulates HNF1alpha. PMID: 9092652
  4. variants of the hepatocyte nuclear factor-1beta (HNF-1beta / TCF2) and the dimerization cofactor of HNF-1 (DcoH/PCBD) genes in relation to type 2 diabetes mellitus and beta-cell function PMID: 11668623
  5. Data reveal DCoH/HNF-1 alpha expression and transcriptional activity in human epidermal melanocytes in vitro and in situ and identified tyrosinase, the key enzyme for pigmentation, as a new transcriptional target. PMID: 12565907
  6. Albumin colocalized together with its transcription factor PCD/DCoH/HNF-1alpha in suprabasal keratinocytes in human full-thickness skin sections and in keratinocytes cultured in serum-free medium. PMID: 15740590
  7. Properties of dehydratase/DCoHalpha are consistent with hypothesis that activity of this isozyme could account for relatively mild symptoms reported for patients with a defect in dehydratase/DCoH PMID: 16423549

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Involvement in disease
Hyperphenylalaninemia, BH4-deficient, D (HPABH4D)
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Pterin-4-alpha-carbinolamine dehydratase family
Database Links

HGNC: 8646

OMIM: 126090

KEGG: hsa:5092

STRING: 9606.ENSP00000299299

UniGene: Hs.3192

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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