PDCL3 Antibody

Datasheet

Code	CSB-PA872479LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: A2780 whole cell lysate, 293 whole cell lysate, U251 whole cell lysate, MCF-7 whole cell lysate, PC-3 whole cell lysate All lanes: PDCL3 antibody at 1:2000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 28 kDa Observed band size: 37 kDa Immunofluorescence staining of HepG2 cells with CSB-PA872479LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PDCL3 Polyclonal antibody

Uniprot No.

Q9H2J4

Target Names

PDCL3

Alternative Names

HTPHLP antibody; IAP associated factor VIAF1 antibody; MGC3062 antibody; PDCL 3 antibody; Pdcl3 antibody; PDCL3_HUMAN antibody; PHLP2A antibody; PHLP3 antibody; Phosducin like 3 antibody; Phosducin like protein 3 antibody; Phosducin-like protein 3 antibody; PhPL3 antibody; VIAF 1 antibody; VIAF antibody; VIAF-1 antibody; VIAF1 antibody; Viral IAP associated factor 1 antibody; Viral IAP-associated factor 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Phosducin-like protein 3 protein (1-239AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PDCL3 Antibody (Product code: CSB-PA872479LA01HU) is Non-conjugated. For PDCL3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA872479LB01HU	PDCL3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA872479LC01HU	PDCL3 Antibody, FITC conjugated
Biotin	CSB-PA872479LD01HU	PDCL3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding. Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes. Modulates the activation of caspases during apoptosis.

Gene References into Functions

results have shown that PhLP2A interacts with Hsp90 and exhibits molecular chaperone activity toward denatured proteins. PMID: 27496612
The data provide new insights for the chaperone function of PDCL3 in angiogenesis and the roles of hypoxia and N-terminal methionine acetylation in PDCL3 expression and its effect on VEGFR-2. PMID: 26059764
data provide strong evidence for the role of PDCL3 in angiogenesis and establishes the molecular mechanism by which it regulates VEGFR-2 expression and function. PMID: 23792958
Data support a model in which Plp2p modulates the biogenesis of several CCT substrates relating to cell cycle and cytoskeletal function, which together contribute to the essential function of PLP2. PMID: 17429077
This publication pertains to mouse. PMID: 12424248

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Subcellular Location

Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum.

Protein Families

Phosducin family

Tissue Specificity

Expressed in endothelial cells (at protein level). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon.

Database Links

HGNC: 28860

OMIM: 611678

KEGG: hsa:79031

STRING: 9606.ENSP00000264254

UniGene: Hs.469459

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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