PDE1C Antibody, FITC conjugated

Datasheet

Code	CSB-PA623901LC01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PDE1C Polyclonal antibody

Uniprot No.

Q14123

Target Names

PDE1C

Alternative Names

5''-cyclic nucleotide phosphodiesterase 1C antibody; Calcium/calmodulin dependent 3'5' cyclic nucleotide phosphodiesterase 1C antibody; Calcium/calmodulin-dependent 3'' antibody; Cam PDE 1C antibody; Cam-PDE 1C antibody; hCam 3 antibody; hCam-3 antibody; HCAM3 antibody; HSPDE1C1A antibody; Human 3'5' cyclic nucleotide Phosphodiesterase antibody; PDE 1C antibody; Pde1c antibody; PDE1C_HUMAN antibody; Phosphodiesterase 1C antibody; Phosphodiesterase 1C calmodulin dependent antibody; Phosphodiesterase 1C calmodulin dependent 70kDa antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Calcium/calmodulin-dependent 3\',5\'-cyclic nucleotide phosphodiesterase 1C protein (542-634AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).

Gene References into Functions

PDE1C is a proliferation-associated gene in glioblastoma multiforme cells in vitro. PMID: 25620587
PDE1C is an important regulator of SMC proliferation, migration, and neointimal hyperplasia, in part through modulating endosome/lysosome-dependent PDGFRbeta protein degradation via low-density lipoprotein receptor-related protein-1. PMID: 25608528
PDE1C levels decreased in all conditions that inhibited proliferation PMID: 16455054
PDE1C1 is expressed at high levels in human cardiac myocytes with an intracellular distribution distinct from that of PDE3A PMID: 17726023

Protein Families

Cyclic nucleotide phosphodiesterase family, PDE1 subfamily

Tissue Specificity

Isoform PDE1C2 is present in the heart and brain and, at lower levels in the lung, liver, kidney and skeletal muscle. Isoform PDE1C1 is expressed in the heart and brain and, at lower levels in lung. Also expressed at low levels in uterus and testis.

Database Links

HGNC: 8776

OMIM: 602987

KEGG: hsa:5137

STRING: 9606.ENSP00000379496

UniGene: Hs.143821

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Calcium signaling pathway

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