PDK4 Antibody

1. Results show that PDK4-specific 5'UTR DNA methylation is positively associated with eicosapentaenoic and arachidonic acid in adult males. PMID: 27181711
2. it was found that low expression of FAM210B was significantly correlated with decreased survival and enhanced metastasis in vivo and in vitro, and the loss of FAM210B led to an increased mitochondrial respiratory capacity and reduced glycolysis through the downregulation of pyruvate dehydrogenase kinase 4 (PDK4). PMID: 28594398
3. In conclusion, our data indicated that PDK4 potentially contributes to the hepatic steatosis in NASH via regulating several signaling pathway and PDK4 may be a new therapeutic strategy against NAFLD. PMID: 29128353
4. Low PDK4 expression is associated with lung tumorigenesis. PMID: 27641336
5. Increased PDK4 expression is associated with colon cancer. PMID: 28208156
6. We found that PDK4 gene and protein expression was significantly elevated in pulmonary arterial hypertension pericytes and correlated with reduced mitochondrial metabolism, higher rates of glycolysis, and hyperproliferation PMID: 27456128
7. Inhibition of CK2 increased the expression of metabolic regulators, PDK4 and AMPK along with the key cellular energy sensor CREB. PMID: 27001465
8. These findings indicate that the TGFbeta/PDK4 signaling axis plays an important role in the response of colorectal cancer to chemotherapy. PMID: 27330076
9. inhibition of PDK4 activity in Hepatocellular carcinoma cells increased cyclin E1, cyclin A2, and E2F1 proteins. PMID: 28003426
10. FXR may promote the proliferation of tumor cells and the hepatocytes in the process of liver regeneration by activating the PDK4-mediated metabolic reprogramming to generate glycolytic intermediates essential for rapid biomass generation, establishing a mechanistic link between cell proliferation and metabolic switch. PMID: 26728993
11. Combined speed endurance and endurance exercise amplify the exercise-induced PGC-1alpha and PDK4 mRNA response in trained human muscle. PMID: 27456910
12. High PDK4 expression is associated with hepatocellular cancer. PMID: 26506419
13. upregulation of PDK4 promotes vascular calcification by increasing osteogenic markers with no adverse effect on bone formation, demonstrating that PDK4 is a therapeutic target for vascular calcification. PMID: 26560812
14. Fatty acids induce the expression of PDK4 mRNA, which was increased in myotubes cultured from obese and T2DM donors. PMID: 25311062
15. Swiss PDB Viewer identifies NFkappaB subunit p100/p49 as a potential interacting partner for PDK4. Relationship between PDK4 and apoptosis is suggested. PMID: 25794976
16. ZBTB2 may increase cell proliferation by reprogramming glucose metabolic pathways to favor glycolysis by upregulating PDK4 expression via repression of RelA/p65 expression PMID: 25609694
17. Methylation increased in PDK4, IL1 B, IL6, and TNF promoters 12 months after gastric bypass. PMID: 24837562
18. PDK4 promotes tumorigenesis through activation of the CREB-RHEB-mTORC1 signaling cascade. PMID: 25164809
19. Data show that the orphan nuclear receptor estrogen related receptor gamma (ERRgamma) plays a critical role in hypoxia-mediated activation of pyruvate dehydrogenase kinase 4 (PDK4) gene expression. PMID: 23050013
20. mRNA of PGC-1alpha and PDK4 increases markedly in both type I and type II skeletal muscle after either continuous or interval exercise PMID: 21883960
21. PDK4 polymorphisms may not be associated with type 2 diabetes or metabolic syndrome. PMID: 22019269
22. The present structures demonstrate the flexible and dynamic aspects of PDK4 in the open conformation and provide a basis for the development of novel inhibitors targeting the nucleotide-binding pocket of PDK4. PMID: 21904029
23. PDK4 gene is downregulated in colic adenocarcinoma. PMID: 20715114
24. The expression of the pyruvate dehydrogenase kinase 4 was downregulated in the failing heart. PMID: 12145475
25. results support the concept that a reduced tissue availability of fatty acids consequent to a massive lipid malabsorption influences glucose metabolism acting through the regulation of pyruvate dehydrogenase kinase 4 PMID: 12582211
26. mRNA levels are increased in skeletal muscle during fasting PMID: 14966024
27. Expression of constitutively active PKB alpha abrogates dexamethasone stimulation of hPDK4 promoter activity. PMID: 15047604
28. Gene expression regulation is affected by retinoic acid and histone acetyation (review). PMID: 15581486
29. activation of FXR may suppress glycolysis and enhance oxidation of fatty acids via inactivation of the pyruvate dehydrogenase complex by increasing PDK4 expression PMID: 15721319
30. retinoic acids (RA) as well as Trichostatin A (TSA), an inhibitor of histone deacetylase (HDAC), regulate PDK4 gene expression PMID: 16757381
31. Accumulation of im lipids plays a more important role than impaired activation of Akt-mediated pathways in the regulation of muscle PDK4 gene expression in lipid-induced acute insulin-resistant states PMID: 17652214
32. PDK4 upregulation in adipocytes participates in the hypolipidemic effect of thiazolidinediones through modulation of glyceroneogenesis PMID: 18519799
33. PDK4 with bound ADP exists in equilibrium between the open and the closed conformations PMID: 18658136

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HGNC: 8812

OMIM: 602527

KEGG: hsa:5166

STRING: 9606.ENSP00000005178

UniGene: Hs.8364