PDSS2 Antibody

Datasheet

Code	CSB-PA773060LA01HU
Size	US$166
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Image	IHC image of CSB-PA773060LA01HU diluted at 1:200 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA773060LA01HU diluted at 1:200 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PDSS2 Polyclonal antibody

Uniprot No.

Q86YH6

Target Names

PDSS2

Alternative Names

All-trans-decaprenyl-diphosphate synthase subunit 2 antibody; bA59I9.3 antibody; C6orf210 antibody; Candidate tumor suppressor protein antibody; chromosome 6 open reading frame 210 antibody; Decaprenyl pyrophosphate synthase subunit 2 antibody; decaprenyl pyrophosphate synthetase subunit 2 antibody; Decaprenyl-diphosphate synthase subunit 2 antibody; DLP1 antibody; DLP1_HUMAN antibody; hDLP1 antibody; Pdss2 antibody; prenyl (decaprenyl) diphosphate synthase; subunit 2 antibody; subunit 2 of decaprenyl diphosphate synthase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Decaprenyl-diphosphate synthase subunit 2 protein (292-387AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PDSS2 Antibody (Product code: CSB-PA773060LA01HU) is Non-conjugated. For PDSS2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA773060LB01HU	PDSS2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA773060LC01HU	PDSS2 Antibody, FITC conjugated
Biotin	CSB-PA773060LD01HU	PDSS2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone. Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9) and ubiquinone-10 (Q10) respectively. The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry. May play a role during cerebellar development. May regulate mitochondrial respiratory chain function.

Gene References into Functions

Results indicate PDSS2 gene which regulates coffee consumption by regulating the expression of the genes linked to caffeine metabolism. PMID: 27561104
PDSS2 encodes a putative tumor suppressor, and its expression is regulated by hypermethylation of its promoter in gastric cancer cells. PMID: 25330808
Decreased PDSS2 expression is an unfavorable prognostic factor for hepatocellular carcinoma, and PDSS2 has potent anticancer activity in HCC tissues and HepG2 cells. PMID: 25780306
Decreased PDSS2 mRNA levels were detected in HCC tissues of 56 patients, correlated with shorter disease-specific survival, and was identified as an independent prognostic factor PMID: 25189544
PDSS2 has tumor-suppressing activity in human lung cancer cells by enhancing apoptosis and inhibiting tumorigenic capacity. PMID: 24608273
Human PDSS2 polymorphisms are associated with podocyte diseases. A deficiency of coenzyme Q10 is manifested in lymphoblastoid cell lines derived from focal segmental glomerulosclerosis patients. PMID: 23926186
Loss of PDSS2 expression is associated with non-small cell lung cancer. PMID: 23312889
Data show that expression of either dlp1 or dps1 recovered the thermo-sensitive growth of an E. coli ispB(R321A) mutant and restored IspB activity and production of Coenzyme Q-8. PMID: 20051244
murine and human solanesyl and decaprenyl diphosphate synthases are heterotetramers composed of newly characterized hDPS1 (mSPS1) and hDLP1 (mDLP1). PMID: 16262699
Expression of PDSS2 is downregulated in human gastric cancer. PDSS2 may be a potent gastric cancer growth suppressor in vitro acting through apoptosis pathways. PMID: 19209031

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Involvement in disease

Coenzyme Q10 deficiency, primary, 3 (COQ10D3)

Subcellular Location

Mitochondrion.

Protein Families

FPP/GGPP synthase family

Database Links

HGNC: 23041

OMIM: 610564

KEGG: hsa:57107

STRING: 9606.ENSP00000358033

UniGene: Hs.745008

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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