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PDXK Antibody

Datasheet
Code CSB-PA017748ESR2HU
Size US$166
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Image
  • Western Blotting(WB) - PDXK Antibody

    Western blot
    All lanes: PDXK antibody at 5.63µg/ml
    Lane 1: Mouse liver tissue
    Lane 2: Hela whole cell lysate
    Lane 3: Mouse kidney tissue
    Lane 4: HepG2 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 36, 32, 27 kDa
    Observed band size: 36 kDa

  • Immunohistochemistry(IHC) 1- PDXK Antibody

    Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA017748ESR2HU at dilution of 1:100

  • Immunohistochemistry(IHC) 2- PDXK Antibody

    Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA017748ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PDXK Polyclonal antibody
Uniprot No.
O00764
Target Names
PDXK
Alternative Names
pdxK antibody; PDXK_HUMAN antibody; PKH antibody; PNK antibody; Pyridoxal kinase antibody; Pyridoxamine kinase antibody; Pyridoxine kinase antibody; Pyridoxine kinase; antibody; Vitamin B6 kinase antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Pyridoxal kinase protein (1-312AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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PDXK Antibodies

PDXK Proteins

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Target Background

Function
Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (Probable). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions.
Gene References into Functions
  1. The affected pyridoxine metabolism is discussed as an inborn genetic trait in epilepsy in general, rather than a specific sign of pyridoxine-dependent epilepsy solely. PMID: 22647618
  2. The pyridoxal kinase showed decreased levels and was highly carbonylated in the gene-on mice PMID: 20639122
  3. This study identified a DNA variant (rs2010795) in PDXK associated with an increased risk of PD in the German cohort This association was confirmed in the British and Italian cohorts individually and reached a combined value. PMID: 20035503
  4. Pyridoxal kinase expression was compared in fetal Down syndrome (DS) brain and controls; PDXK levels were found to be similar. PMID: 15082224
  5. A promoter mutation with potential erythroid-specific properties that could be the basis of a novel mechanism of controlling cell-specific decreased activity of an essential enzyme in erythrocytes. PMID: 16704963
  6. The crystal structure of the MgATP complex also reveals Mg(2+) and Na(+) acting in tandem to anchor the ATP at the active site of pyridoxal kinase. PMID: 17766369
  7. These results document the role of Asp235 in PL kinase activity. PMID: 19351586

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Subcellular Location
Cytoplasm, cytosol.
Protein Families
Pyridoxine kinase family
Tissue Specificity
Ubiquitous. Highly expressed in testis.; [Isoform 3]: In adult testis and spermatozoa.
Database Links

HGNC: 8819

OMIM: 179020

KEGG: hsa:8566

STRING: 9606.ENSP00000291565

UniGene: Hs.284491

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