PELI3 Antibody

Code CSB-PA847618ESR1HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA847618ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA847618ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PELI3 Polyclonal antibody
Uniprot No.
Target Names
PELI3
Alternative Names
E3 ubiquitin protein ligase pellino homolog 3 antibody; MGC35521 antibody; PEL 13 antibody; Peli3 antibody; PELI3_HUMAN antibody; Pellino 3 antibody; Pellino 3 alpha antibody; Pellino E3 ubiquitin protein ligase family member 3 antibody; Pellino homolog 3 (Drosophila) antibody; Pellino-3 antibody; Protein pellino homolog 3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human E3 ubiquitin-protein ligase pellino homolog 3 protein (1-280AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation.
Gene References into Functions
  1. Two protective, low-frequency, non-synonymous variants were significantly associated with a decrease in age-related macular degeneration (AMD)risk: A307V in PELI3 and N1050Y in CFH .We also identified a strong protective signal for a common variant (rs8056814) near CTRB1 associated with a decrease in AMD risk (logistic regression: OR = 0.71, P = 1.8 x 10-07). PMID: 28011711
  2. The combination of low Pellino3 levels together with high and inducible Pellino1 expression may be an important determinant of the degree of inflammation triggered upon Toll-like receptor 2 engagement by Helicobacter pylori and/or its components, contributing to Helicobacter pylori-associated pathogenesis by directing the incoming signal toward an NF-kB-mediated proinflammatory response. PMID: 27302665
  3. Pellino-3 is involved in endotoxin tolerance and functions as a negative regulator of Toll-like receptor 2/4 signaling. PMID: 26310831
  4. Peptide PEL3 derived from the interleukin-1 receptor-associated kinase (IRAK)1-binding motif reveals a distinct phosphothreonine peptide binding preference. PMID: 25027698
  5. Our findings identify RIP2 as a substrate for Pellino3 and Pellino3 as an important mediator in the Nod2 pathway and regulator of intestinal inflammation. PMID: 23892723
  6. Pellino3 is a novel upstream regulator of p38 MAPK that activates CREB in a p38-dependent manner PMID: 15917247
  7. suggest that Pellino 3b acts as a negative regulator for IL-1 signaling by regulating IRAK degradation through its ubiquitin protein ligase activity [Pellino 3b] PMID: 18326498

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Protein Families
Pellino family
Tissue Specificity
Highly expressed in brain, heart and testis, and at lower level in kidney, liver, lung, placenta, small intestine, spleen and stomach. Isoform 1 is not expressed in lung.
Database Links

HGNC: 30010

OMIM: 609827

KEGG: hsa:246330

STRING: 9606.ENSP00000322532

UniGene: Hs.656875

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