PGA3 Antibody, Biotin conjugated

Code CSB-PA11289D0Rb
Size US$299 How to order?
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PGA3 Polyclonal antibody
Uniprot No. P0DJD8
Target Names PGA3
Alternative Names PGA3 antibody; Pepsin A-3 antibody; EC 3.4.23.1 antibody; Pepsinogen-3 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Pepsin A-3 protein (16-388AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
Gene References into Functions
  1. Low Pepsinogen I is associated with precancerous gastric lesions. PMID: 25292040
  2. High serum Pepsinogen I level is associ9ated with the progression of gastric precancerous lesions. PMID: 24895149
  3. Significantly higher AUC was observed for the PGI/PGII ratio and is associated with atrophy and intestinal metaplasia. PMID: 23886209
  4. A significant negative correlation was found between the degree of corpus atrophy and the level of serum pepsinogen-I in atrophic gastritis patients with gastroesophageal reflux. PMID: 21175799
  5. Higher levels of Pepsinogen I is associated with early gastric cancer PMID: 15688378
  6. Helicobacter pylori eradication improves gastric histology and decreases serum gastrin, pepsinogen I and pepsinogen II levels in patients with duodenal ulcer. PMID: 17559360
  7. pepsinogens may have a role in esophageal squamous dysplasia PMID: 18844222
  8. Barrett's esophagus is characterized by the absence of Helicobacter pylori infection and high levels of serum pepsinogen I concentration in Japan. PMID: 19196398

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Subcellular Location Secreted.
Protein Families Peptidase A1 family
Database Links

HGNC: 8885

OMIM: 169700

KEGG: hsa:643834

STRING: 9606.ENSP00000322192

UniGene: Hs.601055

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