PHC1 Antibody

Code CSB-PA017891HA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA017891HA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PHC1 Polyclonal antibody
Uniprot No.
Target Names
PHC1
Alternative Names
Early development regulatory protein 1 antibody; hPH1 antibody; mPH1 antibody; PH1 antibody; Phc1 antibody; PHC1_HUMAN antibody; Polyhomeotic-like protein 1 antibody; Rae28 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Polyhomeotic-like protein 1 protein (142-225AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PHC1 Antibody (Product code: CSB-PA017891HA01HU) is Non-conjugated. For PHC1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA017891HB01HU PHC1 Antibody, HRP conjugated ELISA
FITC CSB-PA017891HC01HU PHC1 Antibody, FITC conjugated
Biotin CSB-PA017891HD01HU PHC1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.
Gene References into Functions
  1. These findings reveal several cellular defects in cells carrying the PHC1 mutation and highlight the role of chromatin remodeling in the pathogenesis of PM. PMID: 23418308
  2. PcG complex 1, involving Rae28 and Cdt1, supports the activity of hematopoietic stem cells by enhancing cycling capability and hematopoietic activity through direct regulation of Geminin PMID: 18650381
Involvement in disease
Microcephaly 11, primary, autosomal recessive (MCPH11)
Subcellular Location
Nucleus.
Database Links

HGNC: 3182

OMIM: 602978

KEGG: hsa:1911

STRING: 9606.ENSP00000251757

UniGene: Hs.744902

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