PHC1 Antibody, HRP conjugated

Datasheet
Code CSB-PA017891HB01HU
Size US$299
Uniprot No. P78364
Protocols ELISA Protocol
Immunogen Recombinant Human Polyhomeotic-like protein 1 protein (142-225AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1), PHC1, EDR1 PH1
Immunogen Species Human
Research Area Epigenetics and Nuclear Signaling
Target Names PHC1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.
Involvement in disease Microcephaly 11, primary, autosomal recessive (MCPH11)
Subcellular Location Nucleus
Database Links

HGNC: 3182

OMIM: 602978

KEGG: hsa:1911

STRING: 9606.ENSP00000251757

UniGene: Hs.744902

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