PHC1 Antibody, Biotin conjugated

Code CSB-PA017891HD01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PHC1 Polyclonal antibody
Uniprot No. P78364
Target Names PHC1
Alternative Names Early development regulatory protein 1 antibody; hPH1 antibody; mPH1 antibody; PH1 antibody; Phc1 antibody; PHC1_HUMAN antibody; Polyhomeotic-like protein 1 antibody; Rae28 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Polyhomeotic-like protein 1 protein (142-225AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.
Gene References into Functions
  1. These findings reveal several cellular defects in cells carrying the PHC1 mutation and highlight the role of chromatin remodeling in the pathogenesis of PM. PMID: 23418308
  2. PcG complex 1, involving Rae28 and Cdt1, supports the activity of hematopoietic stem cells by enhancing cycling capability and hematopoietic activity through direct regulation of Geminin PMID: 18650381
Involvement in disease Microcephaly 11, primary, autosomal recessive (MCPH11)
Subcellular Location Nucleus
Database Links

HGNC: 3182

OMIM: 602978

KEGG: hsa:1911

STRING: 9606.ENSP00000251757

UniGene: Hs.744902

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