PHIP Antibody, FITC conjugated

Code CSB-PA837866LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PHIP Polyclonal antibody
Uniprot No.
Target Names
PHIP
Alternative Names
PHIP antibody; DCAF14 antibody; WDR11 antibody; PH-interacting protein antibody; PHIP antibody; DDB1- and CUL4-associated factor 14 antibody; IRS-1 PH domain-binding protein antibody; WD repeat-containing protein 11 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human PH-interacting protein (508-608AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.
Gene References into Functions
  1. The replication initiation determinant protein PHIP modulates replication by recruiting CUL4 to chromatin. PMID: 30018425
  2. These results provide further support for PHIP as a molecular prognostic marker of melanoma, and reveal a significant linkage between PHIP levels and ulceration. PMID: 24005052
  3. The PHIP gene resides on 6q14.1, and although 6q loss has been observed in melanoma, the PHIP locus was preserved in melanoma cell lines and patient samples, and its overexpression was an independent adverse predictor of survival in melanoma patients. PMID: 22511720
Subcellular Location
Nucleus.
Tissue Specificity
Expressed in myeloma and epidermoid carcinoma cell lines.
Database Links

HGNC: 15673

OMIM: 612870

KEGG: hsa:55023

STRING: 9606.ENSP00000275034

UniGene: Hs.511817

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