PHLDB2 Antibody, FITC conjugated

Code CSB-PA803110LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PHLDB2 Polyclonal antibody
Uniprot No.
Target Names
PHLDB2
Alternative Names
LL5 beta antibody; LL5B antibody; LL5beta antibody; PHLB2_HUMAN antibody; PHLDB2 antibody; Pleckstrin homology-like domain family B member 2 antibody; Protein LL5-beta antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Pleckstrin homology-like domain family B member 2 protein (734-1030AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane.
Gene References into Functions
  1. Prickle1 localized to the membrane through its farnesyl moiety, and the membrane localization was necessary for Prickle1 to regulate migration, to bind to CLASPs and LL5beta, and to promote microtubule targeting of focal adhesions. PMID: 27378169
  2. Collectively, our findings present the first to elucidate that miR-29c is a direct p53 target gene, and also identify PHLDB2 as an important miR-29c target gene involved in colon cancer metastasis. PMID: 28392396
  3. Liprin-alpha1, ERC1a and LL5 also define new highly polarized and dynamic cytoplasmic structures uniquely localized near the protruding cell edge PMID: 24982445
  4. These and other LL5beta-interacting proteins are associated with conventional podosomes in macrophages and podosome-like invadopodia in fibroblasts, strengthening the close relationship between synaptic and non-synaptic podosomes. PMID: 23525008
  5. minor allele, A, intronic single nucleotide polymorphism 'rs951660'in PHLDB2 might induce a delayed splicing and increase the susceptibility to Vascular dementia PMID: 22111664
  6. Signaling from laminin-integrin associations in epithelial cells attaches microtubule plus ends to the epithelial basal cell cortex via PHLDB1 and PHLDB2. PMID: 20513769
  7. LL5beta directs the translocation of filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2. PMID: 20236936
  8. LL5beta and ELKS can form a PIP3-regulated cortical platform to which CLASPs attach distal microtubule ends. PMID: 16824950

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Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane at high levels of PtdIns(3,4,5)P3. At low levels of PtdIns(3,4,5)P3 is translocated to vesicular compartments.
Database Links

HGNC: 29573

OMIM: 610298

KEGG: hsa:90102

STRING: 9606.ENSP00000377502

UniGene: Hs.603252

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