PHLPP1 Antibody

1. Data suggest a tumor suppressor role of Xist in inhibiting AKT activation via regulation of non-X-chromosome gene PHLPP1 expression. PMID: 27248326
2. Low PHLPP expression is associated with gallbladder cancer. PMID: 28212545
3. nickel exposure results in DNMT3b induction and MEG3 promoter hypermethylation and expression inhibition, further reduces its binding to c-Jun and in turn increasing c-Jun inhibition of PHLPP1 transcription, leading to the Akt/p70S6K/S6 axis activation, and HIF-1alpha protein translation, as well as malignant transformation of human bronchial epithelial cells. PMID: 28263966
4. Studies indicate that two PHLPP isozymes, PHLPP1 and PHLPP2, were identified in a search for phosphatases that dephosphorylate Akt, and thus suppress growth factor signaling. PMID: 27913677
5. During LPS induced macrophage inflammatory response, PHLPP levels in macrophages are depleted through the inhibition of SP1 dependent transcriptional regulation. PMID: 28322791
6. Abnormal PHLPP, FoxO3a, and RAD51 protein expressions may be involved in the development of high- and low-grade ovarian serous adenocarcinomas, suggesting common molecular pathways. PMID: 28139510
7. this study shows that PHLPP1 played a suppression role in inflammatory response of glioma PMID: 26971226
8. Increased PHLPP expression is associated with pancreatic cancer. PMID: 26760962
9. our results suggest that PHLPP1 plays a crucial role in sacral chordoma PMID: 26823799
10. high levels of PHLPP might reflect a less aggressive lung adenocarcinoma phenotype and predict better survival in patients with lung adenocarcinoma. PMID: 26463718
11. PHLPP1, along with miR-522, promoted tumor cell growth in glioblastoma cells. PMID: 25776496
12. Suppression of PHLPP1 by DNA methylation contributes to melanoma development and progression. PMID: 24121273
13. PHLPP1 is a binding protein for Mst1 and it modulates the Hippo pathway by dephosphorylating Mst1 at the inhibitory Thr(387) of Mst1. PMID: 24393845
14. our results reveal WDR48 and USP12 as novel PHLPP1 regulators and potential suppressors of tumor cell survival. PMID: 24145035
15. The overall survival time and relapse-free survival time in PHLPP1-positive gastric cancer patients were significantly longer than in PHLPP1-negative patients. PMID: 24037758
16. A hypoxia-induced decrease of PHLPP expression is attenuated by knocking down HIF1alpha but not HIF2alpha. PMID: 24061475
17. Data indicate that binding affinities for the PH domains of Akt and PHLPP1 were greater than for other PH domain-containing proteins, which may underlie the preferential recruitment of these proteins to membranes containing tocopherols. PMID: 23512990
18. we found that SGT1 was able to regulate the stability of PHLPP1, which is the direct phosphatase for Akt ser473 phosphorylation PMID: 23440515
19. USP46-mediated stabilization of PHLPP and the subsequent inhibition of Akt. PMID: 22391563
20. AG490 time-dependently down-regulated the protein expression of PHLPP and induced apoptosis of K562 cells PMID: 22931649
21. Studies suggest that the effects of PHLPP1 deletion on prostate carcinogenesis may be explained by the strong dependence of prostate cancer on phosphoinositide 3-kinase (PI3K)/Akt signalling. PMID: 22340730
22. Loss of PHLPP1 is associated with chronic lymphocytic leukemia. PMID: 22237780
23. a novel USP1-PHLPP1-Akt signaling axis, and decreased USP1 level in lung cancer cells may play an important role in lung cancer progress. PMID: 22426999
24. PHLPP1 has tumor suppressive activity and might represent a therapeutic or diagnostic tool for pancreatic ductal adenocarcinoma. PMID: 22044669
25. show for the first time a significant disruption of all three members of the PTEN-NHERF1-PHLPP1 tumor suppressor network in high-grade tumors, correlating with Akt activation and patient's abysmal survival PMID: 21804599
26. PHLPP as a novel tumor suppressor. PMID: 22144674
27. Knockdown of Scribble (Scrib) results in redistribution of PHLPP1 from the membrane to the cytoplasm and an increase in Akt phosphorylation. PMID: 21701506
28. codeletion of PTEN and PHLPP1 in patient samples is highly restricted to metastatic disease and tightly correlated to deletion of TP53 and PHLPP2 PMID: 21840483
29. Increased abundance of PHLPP-1, production of which is regulated by insulin, may represent a new molecular defect in insulin-resistant states such as obesity. PMID: 21461637
30. the cellular localization of beta-TrCP1 is altered in glioblastoma, resulting in dysregulation of PHLPP1 and other substrates such as beta-catenin. PMID: 21454620
31. a compensatory feedback regulation in which the activation of Akt is inhibited by up-regulation of PHLPP through mTOR, and this mTOR-dependent expression of PHLPP subsequently determines the rapamycin sensitivity of cancer cells. PMID: 21177869
32. Reduced expression of the tumor suppressor PHLPP1 enhances the antiapoptotic B-cell receptor signal in chronic lymphocytic leukemia B-cells. PMID: 20861921
33. Aberrantly expressed UCH-L1 boosts signaling through the Akt pathway by downregulating the antagonistic phosphatase PHLPP1, an event that requires its de-ubiquitinase activity PMID: 20574456
34. In the striatum, reduced levels of PHLPP1 can contribute to maintain high levels of activated Akt that may delay cell death and allow the recovery of neuronal viability after mutant huntingtin silencing PMID: 19745829
35. The PHLPP1 dephosphorylate Mst1 on the T387 inhibitory site, which activate Mst1 and its downstream effectors p38 and JNK to induce apoptosis. PMID: 20513427
36. Mechanism to selectively terminate Akt-signaling pathways through the differential inactivation of specific Akt isoforms by specific PHLPP isoforms. PMID: 17386267
37. PHLPP controls the cellular levels of PKC by specifically dephosphorylating the hydrophobic motif, thus destabilizing the enzyme and promoting its degradation. PMID: 18162466
38. Study focuses on the function of PHLPP1 and PHLPP2 in modulating signaling by Akt and PKC. PMID: 18511290
39. Loss of PHLPP expression is associated with colon cancer. PMID: 19079341
40. demonstrate a key role for beta-TrCP in controlling the level of PHLPP1, and activation of Akt negatively regulates this degradation process. PMID: 19797085

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HGNC: 20610

OMIM: 609396

KEGG: hsa:23239

STRING: 9606.ENSP00000262719

UniGene: Hs.465337