PIK3C3 Antibody, Biotin conjugated

Datasheet
Code CSB-PA854108LD01HU
Size US$299
Uniprot No. Q8NEB9
Immunogen Recombinant Human Phosphatidylinositol 3-kinase catalytic subunit type 3 protein (700-850AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34), PIK3C3, VPS34
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Signal Transduction
Target Names PIK3C3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways
Subcellular Location Midbody, Late endosome, Cytoplasmic vesicle, autophagosome
Protein Families PI3/PI4-kinase family
Tissue Specificity Ubiquitously expressed, with a highest expression in skeletal muscle.
Database Links

HGNC: 8974

OMIM: 602609

KEGG: hsa:5289

STRING: 9606.ENSP00000262039

UniGene: Hs.464971

Pathway Autophagy
Apelin signaling pathway
Phosphatidylinositol signaling system

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