PIK3R4 Antibody

Code CSB-PA785311
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human lymphoma tissue using CSB-PA785311(PIK3R4 Antibody) at dilution 1/85, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA785311(PIK3R4 Antibody) at dilution 1/85, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
PIK3R4
Alternative Names
MGC102700 antibody; P150 antibody; Phosphatidylinositol 3 kinase associated p150 antibody; Phosphatidylinositol 3 kinase regulatory subunit polypeptide 4 antibody; Phosphatidylinositol 3 kinase regulatory subunit polypeptide 4 p150 antibody; Phosphoinositide 3 kinase adaptor protein antibody; Phosphoinositide 3 kinase regulatory subunit 4 antibody; Phosphoinositide 3 kinase regulatory subunit 4 p150 antibody; Phosphoinositide 3 kinase regulatory subunit polypeptide 4 antibody; Phosphoinositide 3 kinase regulatory subunit polypeptide 4 p150 antibody; Phosphoinositide 3-kinase adaptor protein antibody; Phosphoinositide 3-kinase regulatory subunit 4 antibody; PI3 kinase p150 subunit antibody; PI3-kinase p150 subunit antibody; PI3-kinase regulatory subunit 4 antibody; PI3R4_HUMAN antibody; PIK3R 4 antibody; PIK3R4 antibody; VPS 15 antibody; VPS15 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide of Human PIK3R4
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:5000
IHC 1:100-1:300
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2.
Gene References into Functions
  1. A missense mutation in PIK3R4 (phosphoinositide 3-kinase regulatory subunit 4, named VPS15) in a family with a ciliopathy phenotype is identified. Besides being required for trafficking and autophagy, we show that VPS15 regulates primary cilium length in human fibroblasts. PMID: 27882921
  2. Both Danon Disease and glycogen storage disease type II show accumulation and altered localization of VPS15 in autophagy-incompetent fibers. However, TFEB displays a different pattern between these two lysosomal storage diseases PMID: 28102838
  3. High expression of PI3K core complex genes is associated with poor prognosis in chronic lymphocytic leukemia. PMID: 25840748
  4. A specific sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates both receptor degradation and cytokinesis, whereas ATG14L, a PI3K-III subunit involved in autophagy, is not required. PMID: 20643123
  5. hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells PMID: 18957027

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Subcellular Location
Late endosome. Cytoplasmic vesicle, autophagosome. Membrane; Lipid-anchor.
Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family
Tissue Specificity
Ubiquitously expressed.
Database Links

HGNC: 8982

OMIM: 602610

KEGG: hsa:30849

STRING: 9606.ENSP00000349205

UniGene: Hs.149032

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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