PIK3R6 Antibody, Biotin conjugated

Code CSB-PA719469LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PIK3R6 Polyclonal antibody
Uniprot No.
Target Names
PIK3R6
Alternative Names
C17orf38 antibody; Chromosome 17 open reading frame 38 antibody; HsT41028 antibody; p84 PI3K adapter protein antibody; p84 PIKAP antibody; p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein antibody; p87 PI3K adapter protein antibody; p87PIKAP antibody; Phosphatidylinositol 3-kinase; regulatory subunit 6 antibody; Phosphoinositide 3-kinase gamma adapter protein of 87 kDa antibody; Phosphoinositide 3-kinase regulatory subunit 6 antibody; PI3Kgamma adapter protein of 87 kDa antibody; PI3R6_HUMAN antibody; PIK3R6 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Phosphoinositide 3-kinase regulatory subunit 6 protein (566-667AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.
Gene References into Functions
  1. Our findings suggest that p84 binding to p110gamma may represent a novel negative feedback signal that terminates PI3Kgamma activity. PMID: 25753393
  2. expression and activities of PI3Kgamma are modified differently by p87 and p101 in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma signaling pathways. PMID: 24014027
  3. knockdown of p84 in MDA-MB-231 cells enhanced Akt phosphorylation and lung colonization PMID: 21996737
  4. p87PIKAP is a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B [p87PIKAP] PMID: 16476736
  5. ablation of PI3Kgamma reduced SDF1alpha-induced integrin activation in human EPCs and in murine Lin(-) BM-derived progenitor cells PMID: 18323525
  6. RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma PMID: 18596232

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Subcellular Location
Cytoplasm. Cell membrane; Peripheral membrane protein.
Database Links

HGNC: 27101

OMIM: 611462

KEGG: hsa:146850

UniGene: Hs.255809

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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