PLAGL2 Antibody

1. overexpression of miR-449a inhibited the expression of PLAGL2 significantly and the knockdown of PLAGL2 expression inhibited the breast cancer cell proliferation and metastasis PMID: 29653747
2. increased expression correlates to prostate cancer progression following radical prostatectomy and may serve as novel poor prognostic marker PMID: 27537362
3. Our findings indicated that PLAGL2 might be a very upstream key molecule regulating Epithelial-mesenchymal transition involved in Wnt/bcatenin signaling pathway in Colorectal adenocarcinoma PMID: 28259923
4. Our findings indicate that PALGL2 serves as a tumor oncoprotein in the development and progression of colorectal cancer PMID: 25031728
5. PLAGL2 expression induces lamellipodia formation and disruption of stress fiber formation. PMID: 24675530
6. PLAGL2 regulate cell cycle and apoptosis via activation of the p53 family member, p73, in human promonocytic U937 cells. PMID: 22076304
7. Transcriptome analysis revealed that these differentiation-suppressive activities are attributable in part to PLAGL2 modulation of Wnt/beta-catenin signaling PMID: 20478531
8. The data identify PC2 as a novel PLAGL2-binding protein and important mediator of PLAGL2 transactivation. PMID: 20025940
9. PLAGL2 may modulate SP-C expression during lung development. PMID: 15361364
10. Coexpression of Tip60 and PLAGL2 completely abolishes the sumoylation of PLAGL2. PMID: 17551969
11. Nuclear PLAGL2 occupied and transactivated the endogenous SP-C promoter in hypoxic lung cells.These results further suggest that PLAGL2 is an oxidative stress responding regulator in lung cells. PMID: 17618602
12. This study thus uncovers a novel function of PLAGL2 as an oncoprotein through regulating the stability of Pirh2. PMID: 17950244
13. These data suggests that Ubc9 can function as a co-factor of PLAGL2, uncoupling from its enzymatic activity, to mediate PLAGL2 interactive SP-C promoter activity. PMID: 18655774
14. Increased cell injury and/or death could be caused directly by the upregulation of bNip3, a preapoptotic molecule that dimerizes with Bcl-2, or indirectly by the aberrant expression of SP-C-induced endoplasmic reticulum stress in epithelial cells. PMID: 19574421

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HGNC: 9047

OMIM: 604866

KEGG: hsa:5326

STRING: 9606.ENSP00000246229

UniGene: Hs.154104