PLCL1 Antibody

Datasheet

Code	CSB-PA624015LA01HU
Size	US$166
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Image	IHC image of CSB-PA624015LA01HU diluted at 1:300 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA624015LA01HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. Immunofluorescence staining of A549 cells with CSB-PA624015LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PLCL1 Polyclonal antibody

Uniprot No.

Q15111

Target Names

PLCL1

Alternative Names

Inactive phospholipase C-like protein 1 antibody; Inactive protein 1 antibody; Phospholipase C deleted in lung carcinoma antibody; Phospholipase C epsilon antibody; Phospholipase C like 1 antibody; Phospholipase C related but catalytically inactive protein antibody; Phospholipase C related, but catalytically inactive protein antibody; Phospholipase C-deleted in lung carcinoma antibody; Phospholipase C-related but catalytically inactive protein antibody; Phospholipase C-related catalytically antibody; PLC-L1 antibody; PLCE antibody; PLCL antibody; PLCL1 antibody; PLCL1_HUMAN antibody; PLDL1 antibody; PRIP antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Inactive phospholipase C-like protein 1 protein (1-108AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PLCL1 Antibody (Product code: CSB-PA624015LA01HU) is Non-conjugated. For PLCL1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA624015LB01HU	PLCL1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA624015LC01HU	PLCL1 Antibody, FITC conjugated
Biotin	CSB-PA624015LD01HU	PLCL1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.

Gene References into Functions

susceptibility gene for dermatomyositis in Chinese patients with idiopathic inflammatory myopathies PMID: 26603167
PRIP interacts with the catalytic subunits of PP1 and PP2A and the interactions are regulated by phosphorylation. [review] PMID: 23911386
effect of DZP on PRIP-1 knockout mice was reduced PMID: 22128345
In postmenopausal women, our results suggest that the PLCL1 rs7595412 polymorphism has no obvious effect on hip bone size and bone mineral density but may be associated with increased proportion of vertebral fracture and increased levels of osteocalcin PMID: 20030815
PRIP-1 plays an important role in type A receptor signaling for gamma-aminobutyric acid in the brain PMID: 16952428
PLCL1 is a novel gene associated with variation in hip bone size, which has a role in the pathogenesis of hip fractures PMID: 18776929

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Subcellular Location

Cytoplasm.

Tissue Specificity

Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain.

Database Links

HGNC: 9063

OMIM: 600597

KEGG: hsa:5334

STRING: 9606.ENSP00000402861

UniGene: Hs.153322

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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