PLCL1 Antibody

Code CSB-PA624015LA01HU
Size US$166
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Image
  • IHC image of CSB-PA624015LA01HU diluted at 1:300 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA624015LA01HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of A549 cells with CSB-PA624015LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PLCL1 Polyclonal antibody
Uniprot No.
Target Names
PLCL1
Alternative Names
Inactive phospholipase C-like protein 1 antibody; Inactive protein 1 antibody; Phospholipase C deleted in lung carcinoma antibody; Phospholipase C epsilon antibody; Phospholipase C like 1 antibody; Phospholipase C related but catalytically inactive protein antibody; Phospholipase C related, but catalytically inactive protein antibody; Phospholipase C-deleted in lung carcinoma antibody; Phospholipase C-related but catalytically inactive protein antibody; Phospholipase C-related catalytically antibody; PLC-L1 antibody; PLCE antibody; PLCL antibody; PLCL1 antibody; PLCL1_HUMAN antibody; PLDL1 antibody; PRIP antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Inactive phospholipase C-like protein 1 protein (1-108AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PLCL1 Antibody (Product code: CSB-PA624015LA01HU) is Non-conjugated. For PLCL1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA624015LB01HU PLCL1 Antibody, HRP conjugated ELISA
FITC CSB-PA624015LC01HU PLCL1 Antibody, FITC conjugated
Biotin CSB-PA624015LD01HU PLCL1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.
Gene References into Functions
  1. susceptibility gene for dermatomyositis in Chinese patients with idiopathic inflammatory myopathies PMID: 26603167
  2. PRIP interacts with the catalytic subunits of PP1 and PP2A and the interactions are regulated by phosphorylation. [review] PMID: 23911386
  3. effect of DZP on PRIP-1 knockout mice was reduced PMID: 22128345
  4. In postmenopausal women, our results suggest that the PLCL1 rs7595412 polymorphism has no obvious effect on hip bone size and bone mineral density but may be associated with increased proportion of vertebral fracture and increased levels of osteocalcin PMID: 20030815
  5. PRIP-1 plays an important role in type A receptor signaling for gamma-aminobutyric acid in the brain PMID: 16952428
  6. PLCL1 is a novel gene associated with variation in hip bone size, which has a role in the pathogenesis of hip fractures PMID: 18776929

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Subcellular Location
Cytoplasm.
Tissue Specificity
Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain.
Database Links

HGNC: 9063

OMIM: 600597

KEGG: hsa:5334

STRING: 9606.ENSP00000402861

UniGene: Hs.153322

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