OTTHUMP00000020651 antibody; PH domain containing family A member 1 antibody; PH domain-containing family A member 1 antibody; PKHA1_HUMAN antibody; Pleckstrin homology domain containing A1 antibody; Pleckstrin homology domain containing family A member 1 antibody; Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member antibody; Pleckstrin homology domain-containing family A member 1 antibody; PLEKHA1 antibody; Tandem PH domain containing protein 1 antibody; Tandem PH domain-containing protein 1 antibody; TAPP 1 antibody; TAPP-1 antibody; TAPP1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Pleckstrin homology domain-containing family A member 1 protein (285-404AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.
Gene References into Functions
investigated the association of PLEKHA1 958A/G, polymorphisms with Age-Related Macular Degeneration (AMD) risk. PLEKHA1 958A/G polymorphism was associated with a decreased AMD risk (additive model: aOR=0.722, 95% CI=0.450-0.979, P=0.019; allele model: aOR=0.883, 95% CI=0.736-0.992, P=0.014) PMID: 29565837
Studies indicate that the high-risk allele of the 10q26 locus encompasses three genes, PLEKHA1, ARMS2, and HTRA1 with high linkage disequilibrium. PMID: 26427389
CX3CR1 (T280M and V249I) and PLEKHA1 (A320T) polymorphisms were not found to be associated with age-related macular degeneration in an Indian population. PMID: 25050486
This study provides evidence of the joint contribution of genetic variants in PLEKHA1/ARMS2/HTRA1 to age-related macular degeneration risk. PMID: 24013816
TAPP1 binds to protein tyrosine phosphatase PTPL1. PMID: 14516276
syntrophins regulate the localization of TAPP1, which may be important for remodeling the actin cytoskeleton in response to growth factor stimulation PMID: 15485858
PLEKHA1 is strongly implicated as primarily responsible for the evidence of linkage of age-related maculopathy (ARM) to the 10q26 locus and as a major contributor to ARM.susceptibility. PMID: 16080115
Although a role for PLEKHA1 could not be totally excluded, there was a four times higher age-related macular degeneration risk was associated with haplotype "A-T-A" involving "PLEKHA1-LOC387715-HTRA1" risk alleles. PMID: 18079691
Independent of CFH genotype or smoking history, an individual's risk of AMD (age-related macular degeneration) could be increased or decreased, depending on their genotype or haplotype in the 10q26 region. PMID: 18164066