PLEKHA1

PLEKHA1 encodes Pleckstrin homology domain-containing family A member 1, a protein with no widely recognized aliases. It likely functions in intracellular signaling through pleckstrin homology domain-mediated membrane targeting, potentially interacting with phosphoinositides to regulate cytoskeletal dynamics or vesicle trafficking.
Current research links PLEKHA1 to epithelial integrity and cancer progression, though specific signaling pathways remain undefined. Limited evidence suggests associations with breast and colorectal cancers, but no targeted drugs or clinical trials targeting PLEKHA1 have been reported to date.