PLIN5 Antibody

Code CSB-PA804867LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western blot
    All lanes: PLIN5 antibody at 2 μg/ml
    Lane 1: Mouse kidney tissue
    Lane 2: Mouse brain tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 51 kDa
    Observed band size: 51, 36 kDa

  • Immunofluorescent analysis of HepG2 cells using CSB-PA804867LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

The Latest Promotion Free Antibody trial simple
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Description

The PLIN5 polyclonal antibody is inducibly produced in the rabbit immunized by recombinant human PLIN5 (305-453AA). It exists as the IgG isotype and liquid form. And it is purified by protein G and reaches up to 95% in purity. This PLIN5 antibody can react with human- and mouse-origin PLIN5 protein. It can recognize the PLIN5 protein in three applications, including ELISA, WB, and IF. Its target protein PLIN5 is a lipid droplet (LD)-associated protein that plays an important role in regulating the balance between lipolysis and lipogenesis, as well as maintaining the lipid droplet homeostasis. PLIN5 is specifically expressed in oxidative tissues, including cardiac & skeletal muscle, and liver. In high lipid oxidative tissues, PLIN5 exerts a cytoprotective role by promoting lipid storage but limiting fatty acid (FA) metabolism.

Full Product Name Rabbit anti-Homo sapiens (Human) PLIN5 Polyclonal antibody
Uniprot No. Q00G26
Target Names PLIN5
Alternative Names Lipid storage droplet protein 5 antibody; LSDA5 antibody; MLDP antibody; OXPAT antibody; Perilipin 5 antibody; Perilipin-5 antibody; PLIN5 antibody; PLIN5_HUMAN antibody
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human Perilipin-5 protein (305-453AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IF 1:50-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Earn $30 Amazon Card or 20μL/μg CUSABIO Trial Size Antibody. Details of rewards >>

Target Data

Function Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players
Gene References into Functions
  1. The data highlight a key role of PLIN5 in lipid droplets function, first by finely adjusting lipid droplets fatty acids supply to mitochondrial oxidation, and second acting as a protective factor against lipotoxicity in skeletal muscle. PMID: 27922115
  2. Notch1 expression is reduced and glucose-6-phosphatase and perilipin-5 (G6PC/PLIN5) are upregulated in liver biopsies from nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD) patients. PMID: 27428080
  3. High oxygen consumption in middle-aged men was reflected in higher perilipin 5 expression in skeletal muscle. PMID: 26447519
  4. PLIN5 was significantly colocated with ATGL, mitochondria and CGI-58, indicating a close association between the key lipolytic effectors in resting skeletal muscle. PMID: 25054327
  5. Perilipin 5 as a lipid droplet protein adapted to mitochondrial energy utilization PMID: 24535284
  6. Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5 PMID: 23129790
  7. PLIN5 likely plays an important role in intramyocellular lipid accumulation and oxidation, both of which increase with endurance training in human skeletal muscle. PMID: 22667335
  8. The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria. PMID: 22127648
  9. Perilipin 5 is the most recently established family member, highly expressed in oxidative tissues and could play an important role in regulating LD TAG hydrolysis in oxidative mammalian tissues. [Review] PMID: 21632259
  10. interaction of ATGL with CGI-58 increased lipolysis, whereas interaction of ATGL with perilipin 5 decreased lipolysis. PMID: 21393244
  11. Results indicate involvement of OXPAT and ADRP in muscular lipid accumulation and type 2 diabetes. PMID: 19602560

Show More

Hide All

Subcellular Location Lipid droplet, Cytoplasm, Mitochondrion
Protein Families Perilipin family
Tissue Specificity Expressed in skeletal muscle, liver, heart and kidney.
Database Links

HGNC: 33196

OMIM: 613248

KEGG: hsa:440503

STRING: 9606.ENSP00000371272

UniGene: Hs.131034

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

© 2007-2021 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1