PLVAP Antibody

Datasheet

Code	CSB-PA018214GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q9BX97

Target Names

PLVAP

Alternative Names

FELS antibody; Fenestrated endothelial linked structure protein antibody; Fenestrated endothelial-linked structure protein antibody; gp68 antibody; Hypothetical protein DKFZp667O074 antibody; Meca 32 antigen antibody; MECA32 antigen antibody; Panendothelial cell antigen antibody; Plasmalemma vesicle associated protein antibody; Plasmalemma vesicle protein 1 antibody; Plasmalemma vesicle-associated protein antibody; Plvap antibody; PLVAP_HUMAN antibody; PV 1 antibody; PV-1 antibody; PV1 antibody; PV1 protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Human PLVAP

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development.

Gene References into Functions

PV-1 transcription was markedly induced in diabetic retina and by VEGF in retinal endothelial cells PMID: 19284967
Expression of plasmalemma vesicle-associated protein (PLVAP) is increased in endothelial cells in the presence of VEGF PMID: 22200486
In Kimba and Akimba mice fluorescein leakage was associated with focal angiogenesis and correlated significantly with Plvap gene expression. PMID: 24703908
Plasmalemma vesicle-associated protein has a role in vascular permeability PMID: 26878208
The molecule recognized by PAL-E and anti-PV-1 antibodies is not NRP-1 but PV-1. PMID: 22627768
These results suggest that PV1 protein is able to block SV40 infectivity at low but not at high viral concentration either by interfering with the infective internalization pathway at the cell surface or at a post internalization step. PMID: 21827737
Case Report: Suggest activated platelets, enhanced coagulation state, glomerular expression of PV-1 and endothelial damage may contribute to glomerulonephropathy associated with polycythemia vera. PMID: 20979949
PV1 is a key structural component, necessary for the biogenesis of the stomatal and fenestral diaphragms. PMID: 15155804
Plasmalemmal vesicle associated protein-1 has a role in brain tumor angiogenesis PMID: 16278383
leukocyte transendothelial migration is the first known function for PV-1 PMID: 19420356

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Subcellular Location

Cell membrane; Single-pass type II membrane protein. Membrane, caveola; Single-pass type II membrane protein. Cytoplasm, perinuclear region.

Tissue Specificity

Expressed in lung, kidney, heart, aorta, placenta, muscle, pituitary gland, adrenals, mammary gland, bladder, lymph node, bone marrow, trachea, digestive tract, liver and tumor-associated endothelium.

Database Links

HGNC: 13635

OMIM: 607647

KEGG: hsa:83483

STRING: 9606.ENSP00000252590

UniGene: Hs.107125

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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