PLVAP

PLVAP, also known as Plasmalemma vesicle - associated protein, is also commonly referred to as PV - 1. The protein is mainly located in endothelial cells and plays a key role in regulating vascular permeability. It functions by forming channels in the endothelial cell membrane, allowing the passage of various macromolecules.
PLVAP is involved in the VEGFR signaling pathway, which is crucial for angiogenesis. Abnormal expression of PLVAP is associated with diseases such as cancer and diabetic retinopathy. In drug development, targeting PLVAP is considered a potential strategy to control tumor growth and improve vascular abnormalities, though research is still in the pre - clinical stage.