PMS1 Antibody

Code CSB-PA018245GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
PMS1
Alternative Names
DNA mismatch repair protein PMS1 antibody; FLJ98259 antibody; HNPCC3 antibody; hPMS1 antibody; Human homolog of yeast mutL antibody; Mismatch repair gene PMSL1 antibody; pms1 antibody; PMS1 postmeiotic segregation increased 1 (S. cerevisiae) antibody; PMS1 postmeiotic segregation increased 1 antibody; PMS1 protein homolog 1 antibody; PMS1_HUMAN antibody; PMSL1 antibody; Rhabdomyosarcoma antigen MU RMS 40.10B antibody; Rhabdomyosarcoma antigen MU RMS 40.10E antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human PMS1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Probably involved in the repair of mismatches in DNA.
Gene References into Functions
  1. Genome-wide association study identifies variants in PMS1 associated with serum ferritin in a Chinese population. PMID: 25162662
  2. These studies establish that the Mlh1-Pms1 endonuclease is required for MMR in a previously uncharacterized Exo1-independent MMR pathway. PMID: 24204293
  3. PMS1 is most likely deregulated by post-transcriptional modification in oral squamous cell carcinoma. PMID: 23608172
  4. hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA PMID: 11809883
  5. The expression of hMLH1 and hPMS1 was significantly low in some large B-cell lymphomas and in mantle cell lymphomas of the blastoid type and may be related to the natural history of these neoplasms. PMID: 11999575
  6. Data show that DNA damage induces the accumulation of hPMS1, hPMS2, and hMLH1 through ataxia-telangiectasia-mutated (ATM)-mediated protein stabilization. PMID: 15226443
  7. hPMS1 may be useful as CD4+ helper T cell antigens for immunotherapy of pancreatic cancer patients. PMID: 15856462
  8. In pstreplicative mismatch repair, this protein interacts wiwth MutL protein. PMID: 17148452

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Subcellular Location
Nucleus.
Protein Families
DNA mismatch repair MutL/HexB family
Database Links

HGNC: 9121

OMIM: 600258

KEGG: hsa:5378

STRING: 9606.ENSP00000406490

UniGene: Hs.111749

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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