PMS1 Antibody

Datasheet

Code	CSB-PA003824
Size	US$119
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Image	Western Blot analysis of Jurkat cells using PMS1 Polyclonal Antibody Western Blot analysis of various cells using PMS1 Polyclonal Antibody
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P54277

Target Names

PMS1

Alternative Names

DNA mismatch repair protein PMS1 antibody; FLJ98259 antibody; HNPCC3 antibody; hPMS1 antibody; Human homolog of yeast mutL antibody; Mismatch repair gene PMSL1 antibody; pms1 antibody; PMS1 postmeiotic segregation increased 1 (S. cerevisiae) antibody; PMS1 postmeiotic segregation increased 1 antibody; PMS1 protein homolog 1 antibody; PMS1_HUMAN antibody; PMSL1 antibody; Rhabdomyosarcoma antigen MU RMS 40.10B antibody; Rhabdomyosarcoma antigen MU RMS 40.10E antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the Internal region of Human PMS1.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IHC, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:10000

Protocols

Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Probably involved in the repair of mismatches in DNA.

Gene References into Functions

Genome-wide association study identifies variants in PMS1 associated with serum ferritin in a Chinese population. PMID: 25162662
These studies establish that the Mlh1-Pms1 endonuclease is required for MMR in a previously uncharacterized Exo1-independent MMR pathway. PMID: 24204293
PMS1 is most likely deregulated by post-transcriptional modification in oral squamous cell carcinoma. PMID: 23608172
hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA PMID: 11809883
The expression of hMLH1 and hPMS1 was significantly low in some large B-cell lymphomas and in mantle cell lymphomas of the blastoid type and may be related to the natural history of these neoplasms. PMID: 11999575
Data show that DNA damage induces the accumulation of hPMS1, hPMS2, and hMLH1 through ataxia-telangiectasia-mutated (ATM)-mediated protein stabilization. PMID: 15226443
hPMS1 may be useful as CD4+ helper T cell antigens for immunotherapy of pancreatic cancer patients. PMID: 15856462
In pstreplicative mismatch repair, this protein interacts wiwth MutL protein. PMID: 17148452

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Subcellular Location

Nucleus.

Protein Families

DNA mismatch repair MutL/HexB family

Database Links

HGNC: 9121

OMIM: 600258

KEGG: hsa:5378

STRING: 9606.ENSP00000406490

UniGene: Hs.111749

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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