PMS1 Antibody

Code CSB-PA003824
Size US$100
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  • Western Blot analysis of Jurkat cells using PMS1 Polyclonal Antibody
  • Western Blot analysis of various cells using PMS1 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
PMS1
Alternative Names
DNA mismatch repair protein PMS1 antibody; FLJ98259 antibody; HNPCC3 antibody; hPMS1 antibody; Human homolog of yeast mutL antibody; Mismatch repair gene PMSL1 antibody; pms1 antibody; PMS1 postmeiotic segregation increased 1 (S. cerevisiae) antibody; PMS1 postmeiotic segregation increased 1 antibody; PMS1 protein homolog 1 antibody; PMS1_HUMAN antibody; PMSL1 antibody; Rhabdomyosarcoma antigen MU RMS 40.10B antibody; Rhabdomyosarcoma antigen MU RMS 40.10E antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human PMS1.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Probably involved in the repair of mismatches in DNA.
Gene References into Functions
  1. Genome-wide association study identifies variants in PMS1 associated with serum ferritin in a Chinese population. PMID: 25162662
  2. These studies establish that the Mlh1-Pms1 endonuclease is required for MMR in a previously uncharacterized Exo1-independent MMR pathway. PMID: 24204293
  3. PMS1 is most likely deregulated by post-transcriptional modification in oral squamous cell carcinoma. PMID: 23608172
  4. hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA PMID: 11809883
  5. The expression of hMLH1 and hPMS1 was significantly low in some large B-cell lymphomas and in mantle cell lymphomas of the blastoid type and may be related to the natural history of these neoplasms. PMID: 11999575
  6. Data show that DNA damage induces the accumulation of hPMS1, hPMS2, and hMLH1 through ataxia-telangiectasia-mutated (ATM)-mediated protein stabilization. PMID: 15226443
  7. hPMS1 may be useful as CD4+ helper T cell antigens for immunotherapy of pancreatic cancer patients. PMID: 15856462
  8. In pstreplicative mismatch repair, this protein interacts wiwth MutL protein. PMID: 17148452

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Subcellular Location
Nucleus.
Protein Families
DNA mismatch repair MutL/HexB family
Database Links

HGNC: 9121

OMIM: 600258

KEGG: hsa:5378

STRING: 9606.ENSP00000406490

UniGene: Hs.111749

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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