POLR2D Antibody

Code CSB-PA018331GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
POLR2D
Alternative Names
DNA directed RNA polymerase II 16 kDa polypeptide antibody; DNA directed RNA polymerase II subunit D antibody; DNA directed RNA polymerase II subunit RPB4 antibody; DNA-directed RNA polymerase II 16 kDa polypeptide antibody; DNA-directed RNA polymerase II subunit D antibody; DNA-directed RNA polymerase II subunit rpb4 antibody; HSRBP4 antibody; HSRPB4 antibody; polr2d antibody; polymerase RNA II DNA directed polypeptide D antibody; RBP4 antibody; RNA polymerase II 16 kDa subunit antibody; RNA polymerase II subunit B4 antibody; RNA polymerase II subunit D antibody; RNA polymerase II subunit hsRBP4 antibody; RPB16 antibody; RPB4_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human POLR2D
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA.
Gene References into Functions
  1. Identification of the RNA binding region of Rpb4. PMID: 16282592
Subcellular Location
Nucleus.
Protein Families
Eukaryotic RPB4 RNA polymerase subunit family
Database Links

HGNC: 9191

OMIM: 606017

KEGG: hsa:5433

STRING: 9606.ENSP00000272645

UniGene: Hs.715348

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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